In recent years, researchers have become increasingly aware of the fact that epigenetic alterations can contribute to the formation of multiple myeloma (MM); however, our understanding of these remain unclear. In this interview, Felipe Prosper Cardoso, MD, of the University of Navarra, Pamplona, Spain, gives an insightful overview of the high-throughput technologies currently being used to investigate these epigenetic mechanisms, including ChIP-sequencing, chromosome conformation capture-on-chip (4C), and bisulfite sequencing. This video was recorded at the Myeloma 2017 meeting, held in Edinburgh, UK.