Functional imaging techniques serve an essential role in diagnostics. Here, Elena Zamagni, MD, PhD, of the University of Bologna, Bologna, Italy, highlights the important applications of PET/CT in multiple myeloma (MM) management at the European School of Haematology (ESH) International Conference on MM 2018, held in Mandelieu, France. Dr Zamagni identifies the importance of PET/CT in MM mapping, prognosis, diagnose and management, while reflecting on the progress in standardizing the use of the technique in evaluating the response to therapy outside of the bone marrow.