Although genetics and epigenetics serve an important role in the efficacy of novel agents such as ibrutinib, other factors must also be considered. Here, Francesco Forconi, MD, DM, PhD, FRCPath, of the University of Southampton, Southampton, UK, explains the importance of investigating the environment in which chronic lymphocytic leukemia (CLL) cells thrive. In this interview, he highlights the importance of studying the lymph nodes and environmental stimuli that can affect BCL-2 signaling, CLL cell survival and cell death. This interview was recorded at the American Society of Hematology (ASH) 2017 Annual Meeting and Exposition in Atlanta, GA.
What can we learn about CLL by studying environmental stimuli?
