Viruses such Epstein-Barr virus (EBV) and HIV have been aetiologically linked to a significant number of lymphoproliferative diseases. In this roundtable discussion, lead by Catherine Bollard, MBChB, MD, FRACP, FRCPA, of the Children’s National Health System, Washington, DC, Dr Bollard covers the risk factors for viral lymphomas, as well as the current landscape for therapy and trial participation. She is joined by Ruth Jarrett, MD, PhD, from the University of Glasgow Center for Virus Research, Glasgow, UK, Mark Roschewski, MD, of the National Cancer Institute, Bethesda, MD, and Richard Little, MD, of the National Cancer Institute, Rockville, MD, at the International Workshop on Non-Hodgkin Lymphoma (iwNHL) 2018 meeting, held in Nice, France.