OncologyTube.com is the first and only free video sharing website dedicated to helping oncology professionals spread knowledge about cancer research through video, audio and other multimedia.
    • OncologyTube Cancer Articles, News and Videos

      Site: OncologyTube Cancer Articles, News and Videos

    • Products & Pricing
      • Banner Advertising Plans
      • eNewsletter Packages
      • Pre-Roll Advertising
      • Create A Deep Dive Conversation
      • Create a Video Release (VR)
      • Boost Earned Media Only $60
    • 0
      • Portuguese
      • Spanish
      • Italian
      • Greek (Greece)
      • Sinhala
      • Polish
      • Arabic (Saudi Arabia)
      • Swedish (Sweden)
      • Portuguese (Brazil)
      • Hindi (India)
      • English (Australia)
      • Hebrew (Israel)
      • Czech
      • Chinese
      • Turkish
      • Japanese (Japan)
      • Dutch
      • French
      • German
      • Chinese (Traditional Han, Taiwan)
      • Korean (South Korea)
      • Thai
      • Spanish (Chile)
      • English (United States)
      • Russian
      • Danish (Denmark)
  • Home
  • Trending

  • Inloggen

  • Quick Links
  • Schedule A Remote Interview!
  • Check Out Our Blog
  • Buy Advertising Banners
  • Buy Pre-Roll Advertisements
  • Boost Your Earned Media starting at Just $60
  • Create A Deep Dive Conversation
  • Advertising Specifications
  • Our Editorial Process

  • Audio en Video
  • Video's
  • Audio

  • Channels
  • Browse Channels

  • Categorieën
  • Acute Lymphoblastic Leukemia 5588
  • Acute Myelogenous Leukemia 222
  • Bladder 96
  • Bone Metastases 5
  • Brain 79
  • Breast 523
  • Business Management 5
  • Cervical 16
  • Chronic Lymphocytic Leukemia 208
  • Chronic Myelogenous Leukemia 54
  • Colorectal 169
  • Conference Coverage 1
  • COVID-19 43
  • Gastrointestinal 177
  • General 341
  • Genitourinary 3
  • Head and Neck 110
  • Help 3
  • Hematologic Malignancies 204
  • Hodgkin Lymphoma 31
  • Imaging 2
  • Immunotherapy 179
  • Kidney 392
  • Liver 40
  • Lung 89
  • Lymphoma 232
  • Melanoma and Skin 107
  • Multiple Myeloma 533
  • Myeloproliferative Disease 37
  • News 149
  • Non-Hodgkin Lymphoma 81
  • Non-Small Cell Lung Cancer 551
  • Other 517
  • Ovarian 65
  • Pancreatic 100
  • Patient Resources 51
  • Pediatric 7
  • Prostate 300
  • Sarcoma 13
  • Sickle Cell 22
  • Small Cell Lung Cancer 81
  • Supportive Care 51
  • Testicular 3
  • Urology 16
  • Uterine 9

  • Install
  • Play a Link
  • Over
  • Contact
  • Acute Lymphoblastic Leukemia
  • Acute Myelogenous Leukemia
  • Bladder
  • Bone Metastases
  • Brain
  • Breast
  • Business Management
  • Cervical
  • Chronic Lymphocytic Leukemia
  • Chronic Myelogenous Leukemia
  • Colorectal
  • Conference Coverage
  • COVID-19
  • Gastrointestinal
  • General
  • Genitourinary
  • Head and Neck
  • Help
  • Hematologic Malignancies
  • Hodgkin Lymphoma
  • Imaging
  • Immunotherapy
  • Kidney
  • Liver
  • Lung
  • Lymphoma
  • Melanoma and Skin
  • Multiple Myeloma
  • Myeloproliferative Disease
  • News
  • Non-Hodgkin Lymphoma
  • Non-Small Cell Lung Cancer
  • Other
  • Ovarian
  • Pancreatic
  • Patient Resources
  • Pediatric
  • Prostate
  • Sarcoma
  • Sickle Cell
  • Small Cell Lung Cancer
  • Supportive Care
  • Testicular
  • Urology
  • Uterine
Endocrine Therapy: SABCS 2022 Halle Moore POSITIVE Trial Breast Cancer
0:07:17

Endocrine Therapy: SABCS 2022 Halle Moore POSITIVE Trial ...

Endocrine Therapy: SABCS 2022 Halle Moore POSITIVE Trial Breast Cancer

How does endocrine therapy (aromatase inhibitor) effect women with endocrine responsIVE breast cancer? The POSITIVE study which was presented at this year's San Antonio Breast Cancer Symposium (SABCS) was a prospective clinical trial designed to evaluate the safety of and pregnancy outcomes with interrupting endocrine therapy for early stage hormone receptor positive breast cancer in order to attempt pregnancy.

 

Young women with early stage hormone receptor positive breast cancer were eligible for the trial if they desired pregnancy and had completed 18 to 36 months of adjuvant endocrine therapy. Following enrollment participants stopped their endocrine treatments for at least 3 months prior to attempting pregnancy to allow for a washout period of the medications, and the intent was that participants would be off of their endocrine treatment for no more than about 2 years to allow that washout period.

 

Attempting pregnancy, completing pregnancy if able as well as any nursing if desired or possible, and breast cancer patients were then encouraged to resume the endocrine therapy to complete their planned treatment course. The primary endpoint of the clinical trial was breast cancer free interval, and based on prior studies, it was felt that the annual risk of recurrence should not exceed about 4% in this population.

 

And if it did exceed that number, that would indicate a safety concern for interrupting pregnancy, interrupting endocrine therapy (aromatase inhibitor) during pregnancy. In addition to providing a comparison in the analysis, the participants in the POSITIVE study were matched with similar participants in the SOFT and TEXT trials. And those were studies looking at different endocrine treatments for premenopausal early stage breast cancer.

 

And the trial also looked at pregnancy related outcomes. So the results from the primary study endpoint showed that the rate of breast cancer free interval events at 3 years was 8.9%. That was actually very similar to the breast cancer free interval event rate that had been observed in the matched breast cancer patients in the SOFT and TEXT clinical trials, where the event rate was 9.2%.


So, at least in the short term, it appears that interrupting endocrine therapy to attempt pregnancy is indeed safe. The study also looked at pregnancy outcomes, about 74% of the participants had become pregnant at the time of the data analysis, and about 64% of trial participants had at least one live birth at the time of the analysis.

 

So far, there have been a total of 365 babies born to participants on this study and that those came from 317 individual women. And most of these participants did end up resuming their endocrine treatment after completing the planned pregnancies. So these findings really provide reassurance for young women with hormone receptor positive breast cancer who wish to become pregnant.

 

There's no suggestion of an increased (high) risk of recurrence at 3 years in spite of temporary interruption of their treatment. So hopefully these findings can help guide breast cancer patients and their providers to make the best decisions for themselves regarding interrupting treatment to attempt pregnancy. Of course, long-term follow up will be very important and there is a plan to continue to observe this population for 10 years.

 

Read and Share the Article Here: https://oncologytube.com/v/41573

Listen and Share the Audio Podcast Here: https://oncologytube.com/v/41574

 

What is Endocrine Therapy in Premenopausal Women with Breast Cancer?

Frequently, premenopausal women with breast malignancies that express the estrogen and/or progesterone receptor (ER and/or PR-positive) are advised to take tamoxifen for five years. This medication inhibits the actions of estrogen on cancer cells and reduces the chance of breast cancer recurrence in women of any age by about 50 percent.

Tamoxifen can also lessen the risk of developing a new breast cancer in the breast that is not currently affected. In some instances, women younger than 35 to 40 years of age may also be considered for combination endocrine therapy with drugs that temporarily inhibit ovarian function.

Despite the absence of menstruation, it is likely that these women still have functioning ovaries and premenopausal hormone levels. Additionally, ovarian function may return unexpectedly. Thus, aromatase inhibitors should not be recommended to premenopausal women, regardless of whether they experience temporary menopause due to medication (unless they are participating in specific clinical research studies). Aromatase inhibitors are typically reserved for women with breast cancer who are postmenopausal.

Tamoxifen side effects are often modest and diminish over time. They consist of:

  • Warm flashes

  • Vaginal discharge

  • Menstrual irregularity

  • Hair loss

  • Skin changes

  • Reduced desire for sexual activities

  • Fertility problems

  • Memory impairment

  • Fatigue

  • Joint discomfort

  • Headaches

  • insomnia or sleep disturbances

  • increased perspiration

  • Nausea

  • Weight changes

  • Mood swings

Some negative effects can be mitigated with symptom management and other lifestyle modifications.

Risk Factors

Blood clots (deep venous thrombosis or pulmonary embolism) or uterine (endometrial) cancer are among the rare but severe side effects of tamoxifen, especially in women less than 50 years old.

 

What are the most common questions you're asked by your colleagues about this breast cancer trial?  

So one of the questions that people have asked is whether there was a difference in outcomes among breast cancer patients who actually became pregnant versus those who did not become pregnant while on the study,  and that was analyzed. For breast cancer patients who became pregnant within the first 18 months of follow up, there was no increase in the risk of recurrence, you know, related to pregnancy, hormones, et cetera.

And if anything those breast cancer patients who became pregnant actually appeared to do a little better than those who did not become pregnant. In terms of how these data will affect our practice today, I think it really informs our discussions with our breast cancer patients. A decision to attempt pregnancy following a cancer diagnosis can be very complex, particularly in the setting of hormone sensitive cancer and when long-term treatment is not compatible with pregnancy. So some breast cancer patients may wait until completing 5 to 10 years of hormonal treatment before attempting pregnancy, and they might experience more fertility concerns because they will be older at that time.

 

Other breast cancer patients might choose not to take hormonal treatment for their cancer at all because pregnancy might be so important to them. So I think this study really provides an approach that seems to provide a safe balance between appropriately treating the cancer and improving the prospects for pregnancy.

 

What is the next step for this research in hormone therapy?  

And again, I think in terms of next step for this research, it's really going to be important to have that long-term follow up. There are also a number of translational research projects that will look at ovarian reserve, ovarian function, as well as, circulating tumor DNA, which might help to inform future pregnancies.

 

What are the key takeaways from this trial on hormone therapy drugs?  

I think oncologists should take away from this that, in the short term, a temporary interruption of endocrine (adjuvant therapy) treatment for pregnancy does not appear to increase the risk of breast cancer recurrence. However, recurrences do happen, so it is important to discuss with breast cancer patients their individual breast cancer risk factors of distant recurrence as they contemplate this very complex decision about pregnancy following a breast cancer diagnosis.

 

What are your final thoughts?  

So I think the fact that this trial enrolled so well, underscores the importance for many young women of having children even after a breast cancer diagnosis. And I would remind clinicians not to wait until treatment completion to discuss these issues. Rather, concerns related to future fertility should really be discussed as early as possible following a breast cancer diagnosis in order to expand the options available to these patient.

 

Halle Moore, MD - About The Author, Credentials, and Affiliations

Halle Moore, MD, is the Director of Breast Medical Oncology in the Cleveland Clinic Taussig Cancer Institute's Department of Hematology and Oncology. She is Co-Director of the Comprehensive Breast Cancer Program at the Cleveland Clinic. She is also board-certified in medical oncology and an associate professor of medicine at the Cleveland Clinic Lerner College of Medicine. She completed a residency in internal medicine at the University Hospitals of Cleveland and a fellowship in hematology and medical oncology at the Hospital of the University of Pennsylvania.

 

Dr. Moore is an expert in the medical therapy of breast cancer from a clinical standpoint. Her research focuses on breast cancer treatment and cancer survivorship issues. She was the principal investigator and author of the practice-altering New England Journal of Medicine article describing the POEMS research establishing a way for protecting ovarian function during breast cancer adjuvant chemotherapy treatment in young women. Dr. Moore is co-chair of the national Survivorship Committee for the SWOG Cancer Research Network and a member of the Survivorship Panel for the National Comprehensive Cancer Network Clinical Practice Guidelines.

 

 

657 Views
1 maand Geleden
SABCS
Toevoegen aan
Want to watch this again later?
Sign in to add this video to a playlist. Inloggen

Breast Beschrijving
Breast Cancer

Types of Imaging Tests for Breast Cancer - 2022 Program: Testing and Early Diagnosis
0:03:01
Types of Imaging Tests for Breast Cancer - 2022 Program: ...
2 Views
2 weeks Geleden
Cancer
Toevoegen aan
Want to watch this again later?
Sign in to add this video to a playlist. Inloggen
Prevalence of Breast Cancer and Tools for Early Detection -2022 Program: Testing and Early Diagnosis
0:03:45
Prevalence of Breast Cancer and Tools for Early Detection...
2 Views
2 weeks Geleden
Cancer
Toevoegen aan
Want to watch this again later?
Sign in to add this video to a playlist. Inloggen
Sociodemographic: SABCS 2022 Megan Kruse Disparities in AYA Breast Cancer
0:06:37
Sociodemographic: SABCS 2022 Megan Kruse Disparities in A...
297 Views
3 weeks Geleden
SABCS
Toevoegen aan
Want to watch this again later?
Sign in to add this video to a playlist. Inloggen
Sociodemographic: SABCS 2022 Megan Kruse Disparities in AYA Breast Cancer
0:06:20
Sociodemographic: SABCS 2022 Megan Kruse Disparities in A...
9 Views
3 weeks Geleden
SABCS
Toevoegen aan
Want to watch this again later?
Sign in to add this video to a playlist. Inloggen
Sociodemographic: SABCS 2022 Megan Kruse Disparities in AYA Breast Cancer
Sociodemographic: SABCS 2022 Megan Kruse Disparities in A...
4 Views
3 weeks Geleden
SABCS
Toevoegen aan
Want to watch this again later?
Sign in to add this video to a playlist. Inloggen
DESTINY-Breast03: SABCS 2022 Sara Hurvitz Updated Survival Results
0:08:25
DESTINY-Breast03: SABCS 2022 Sara Hurvitz Updated Surviva...
6 Views
3 weeks Geleden
SABCS
Toevoegen aan
Want to watch this again later?
Sign in to add this video to a playlist. Inloggen
DESTINY-Breast03: SABCS 2022 Sara Hurvitz Updated Survival Results
DESTINY-Breast03: SABCS 2022 Sara Hurvitz Updated Surviva...
15 Views
3 weeks Geleden
SABCS
Toevoegen aan
Want to watch this again later?
Sign in to add this video to a playlist. Inloggen
DESTINY-Breast03: SABCS 2022 Sara Hurvitz Updated Survival Results
0:08:59
DESTINY-Breast03: SABCS 2022 Sara Hurvitz Updated Surviva...
465 Views
3 weeks Geleden
SABCS
Toevoegen aan
Want to watch this again later?
Sign in to add this video to a playlist. Inloggen
IHC 0 HER2: SABCS 2022 Gerard Oakley Deep Learning-Based Assessment
0:22:47
IHC 0 HER2: SABCS 2022 Gerard Oakley Deep Learning-Based ...
9 Views
3 weeks Geleden
SABCS
Toevoegen aan
Want to watch this again later?
Sign in to add this video to a playlist. Inloggen
IHC 0 HER2: SABCS 2022 Gerard Oakley Deep Learning-Based Assessment
IHC 0 HER2: SABCS 2022 Gerard Oakley Deep Learning-Based ...
75 Views
3 weeks Geleden
SABCS
Toevoegen aan
Want to watch this again later?
Sign in to add this video to a playlist. Inloggen
IHC 0 HER2: SABCS 2022 Gerard Oakley Deep Learning-Based Assessment
0:26:10
IHC 0 HER2: SABCS 2022 Gerard Oakley Deep Learning-Based ...
678 Views
3 weeks Geleden
SABCS
Toevoegen aan
Want to watch this again later?
Sign in to add this video to a playlist. Inloggen
RxPONDER: SABCS 2022 Yara Abdou Racial Disparities SWOG S1007
0:06:36
RxPONDER: SABCS 2022 Yara Abdou Racial Disparities SWOG S...
8 Views
1 maand Geleden
SABCS
Toevoegen aan
Want to watch this again later?
Sign in to add this video to a playlist. Inloggen

Copyright 2023 Medicus Networks, Inc. 45121 Morgan Heights Rd. Temecula, CA 92592