Giovanni Pellacani, MD of the University of Modena and Reggio Emilia, Modena, Italy, discusses the challenges surrounding the idea of getting multiphoton microscopy techniques to the clinical in skin cancer. First, Prof. Pellacani explains that a larger surface of the tumor should be explored using this technique, as this will enable for a more definitive diagnosis for patients. Secondly, the affordability and costs associated with the running of the machine should be explored, allowing it to be more readily used to help to diagnose patients. Recorded at the 2016 World Congress on Cancers of the Skin (WCCS) and the Congress of the European Association of Dermato-Oncology (EADO) in Vienna, Austria.