There were impressive updates on venetoclax combination studies for elderly acute myeloid leukemia (AML) that are progressing at the American Society of Hematology (ASH) 2017 Annual Meeting and Exposition in Atlanta, GA. Speaking from the meeting, Marina Konopleva, MD, PhD, from the University of Texas MD Anderson Cancer Center, Houston, TX, discusses the studies, including the combination of venetoclax with azacitidine/decitabine (NCT02203773), low-dose cytarabine (NCT02287233), and cobimetinib and idasanutlin (NCT02670044). Dr Konopleva explains the exciting data so far, highlighting the utility of these new treatments, which are much needed for elderly AML, where treatment options are very limited.