A large contributing factor to outcome in amyloidosis is the stage of diagnosis. Here, Giampaolo Merlini, MD, from the University of Pavia, Paiva, Italy, discusses the need to improve outcomes in patients with very advanced (stage IIIb) cardiac amyloid light-chain (AL) amyloidosis. Dr Merlini emphasises the importance of early diagnosis for this patient population using biomarkers and imaging, to supress the light-chains amyloid deposits early on, and change the outlook of these patients. This video was recorded at the 1st European Myeloma Network Meeting, in Turin, Italy.