At the German Cancer Congress 2016, held in Berlin, Germany, from 24 to 27 February 2016, Lorenz Trümper, MD, from University Hospital of Göttingen, Göttingen, Germany, discusses significant advances in the treatment of lymphoma, including approaches that decrease the toxicity and increase the efficacy of chemotherapy; and approaches that reduce the use of chemotherapy, such as monoclonal antibodies and chimeric antigen receptor (CAR) T-cell therapy.