Thrombosis is the leading cause of morbidity and mortality in paroxysmal nocturnal hemoglobinuria (PNH). In this interview, Anita Hill, MBChB (Hons), MRCP, FRCPath, PhD, from Leeds Teaching Hospital NHS Trust, Leeds, UK, speaks about the complication that is thrombosis, which despite technical advancements is still not being picked up quickly enough. Current interventions involve evaluating clot structures and manipulating them for clot relief. This interview was recorded at the British Society for Haematology (BSH) 2018 Annual Scientific Meeting, held in Liverpool, UK.