The utilization of CAR T-cells for the treatment of multiple myeloma (MM) has great potential, with numerous different targets and production approaches. In this video, this exciting upcoming area is discussed by Adam Cohen, MD from the Abramson Cancer Center, Philadelphia, PA, Yi Lin, MD, PhD from the Mayo Clinic, Rochester, MD and Sabrina Prommersberger, PhD from the University Hospital Würzburg, Würzburg, Germany at the engaging Myeloma 2017 meeting in Edinburgh, UK. The experts summarize the promising findings of CAR T-cell clinical trials in MM patients thus far, including NCT02546167 and NCT02658929. Looking towards the future, the speakers discuss the next steps for the use of CAR T-cells in MM and what updates we can expect at the American Society of Hematology (ASH) 2017 annual meeting.