Anas Younes, MD, from the Memorial Sloan Kettering Cancer Center, New York, NY is joined by Eduardo Sotomayor, MD, from the George Washington University School of Medicine & Health Sciences, Washington, D.C, and Laura Pasqualucci, MD, from the Columbia University Medical Center, New York, NY, at the 2017 International Workshop in Non-Hodgkin Lymphoma (iwNHL) in Vancouver, BC, Canada. They discuss the results of large sequencing studies, and the role of epigenetic modulators in the pathogenesis of lymphomas.