Here, Robin Foà , MD, from the University of Rome, Rome, Italy, discusses the potential of a chemotherapy-free strategy for patients with acute lymphoblastic leukemia (ALL). Speaking from the 2018 European School of Hematology (ESH) Clinical Updates on Acute Leukemias, held in Budapest, Hungary, Prof. Foà points to that fact patients have achieved remission, and even measurable residual disease (MRD) negativity.