Faith Davies, MBBCh, MRCP, MD, FRCPath from UAMS Myeloma Institute, Arkansas, AZ discusses the importance of the microenvironemt in multiple myeloma at the Myeloma 2016 meeting held in Boston, MA. In light of findings that have established the importance of the microenvironment, Prof Davies further talks about the possibility of new drug combinations, such as combining HDAC inhibitors with immune check-point inhibitors.