The development of IDH inhibitors for acute myeloid leukemia (AML) has been a smoother journey than that for FLT3 inhibitors. Speaking from the American Society of Hematology (ASH) 2017 Annual Meeting and Exposition in Atlanta, GA, Richard Stone, MD, of the Dana-Farber Cancer Institute, Boston, MA, provides a comprehensive summary of the use of IDH inhibitors for acute myeloid leukemia (AML) treatment. Dr Stone covers the successful trial and subsequent approval of enasidenib for IDH2-mutated advanced AML, as well as the highly anticipated results of a trial investigating ivosidenib monotherapy for IDH1-mutated AML that were presented at the meeting (NCT02074839). Furthermore, he highlights exciting further trials of these drugs in combination regimens that were presented at the meeting (NCT02632708, NCT02677922).
The future of AML treatment? Progress in IDH1/2 inhibitors for AML
