Research into imaging for multiple myeloma (MM) is expanding into an exciting new field, which is explored in this discussion by Jens Hillengass, MD, from the University Hospital Heidelberg, Heidelberg, Germany, and Saad Usmani, MD, FACP, from the Levine Cancer Institute, Charlotte, NC, at the Myeloma 2017 meeting in Edinburgh, UK. They discuss the heterogeneity of MM, as as well as focal lesions, liquid biopsies and CT as the new standard of imaging for diseases of the bone marrow.