There are currently several novel agents that target non-coding RNAs being tested in pre-clinical studies for the treatment of leukemia. In this video, Ramiro Garzon, MD, from the Ohio State University, Columbus, OH, discusses these exciting candidates and talks about the drug development process. This video was recorded at the International Conference on Acute Myeloid Leukaemia 2017 in Estoril, Portugal by the European School of Hematology (ESH).