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Sacituzumab Govitecan, a Novel Treatment for Patients with mTNBC
00:47:05

Sacituzumab Govitecan, a Novel Treatment for Patients with mTNBC

In this episode of The Onco'Zine Brief, Peter Hofland talks with Thorsten Sperber, Global Head Medical Affairs at Immunomedics.

Hofland and Sperber talk about sacituzumab govitecan, a novel antibody-drug conjugate. At the time of the interview, the drug was not yet approved, but in the weeks following the interview, the U.S. Food and Drug Administration (FDA) approved sacituzumab govitecan (Trodelvy™) for the treatment of adult patients with metastatic triple-negative breast cancer (mTNBC) who have received at least two prior therapies for patients with relapsed or refractory metastatic disease.

Sacituzumab govitecan, previously known as IMMU-132, is Immunomedics’ lead product and the most advanced program in the company’s unique antibody-drug conjugate (ADC) platform. The drug binds the humanized anti-trophoblast cell-surface antigen 2 (Trop-2) monoclonal antibody (mAb) hRS7 IgG1κ through the cleavable CL2A linker to the anti-cancer drug SN-38 to kill cancer cells. Trop-2 is expressed in more than 85% of all cancers, including breast cancer and TNBC.

With the FDA’s decision, sacituzumab govitecan is the eight approved and available ADCs reaching the market, making these targeted drugs a powerful class of therapeutic agents in oncology and hematology.

About The Onco'Zine Brief
The Onco'Zine Brief is distributed in the United States via PRX (Public Radio Exchange). In the United Kingdom and Europe, the program is distributed via UK Health Radio (UKHR). And the program can be downloaded via most podcasts and streaming media services, including iTunes, Spotify, TuneIn, and iHeart Radio.

For more information about The Onco'Zine Brief or how to sponsor or support this public radio broadcast and podcast click on the link to visit our Patreon page.

For more information about cancer and cancer treatments, click on the link to visit our online journal Onco'Zine.

To sign up for The Onco'Zine Newsletter (open for residents of the United States only), text the word CANCER to 66866.

 

Breast
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2 years Ago
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Elacestrant: FDA Grants Approval for Breast Cancer Treatment: Insights from Virginia Kaklamani
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FLEX Trial Breast Cancer: SABCS 2022 Mehran Habibi MD Looking at Gene Mutations
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FLEX Trial Breast Cancer: SABCS 2022 Mehran Habibi MD Looking at Gene Mutations
FLEX Trial Breast Cancer: SABCS 2022 Mehran Habibi MD Looking at Gene Mutations
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Elacestrant: FDA Grants Approval for Breast Cancer Treatment: Insights from Virginia Kaklamani
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Elacestrant: FDA Grants Approval for Breast Cancer Treatment: Insights from Virginia Kaklamani
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FLEX Trial Breast Cancer: SABCS 2022 Mehran Habibi MD Looking at Gene Mutations
0:05:31
FLEX Trial Breast Cancer: SABCS 2022 Mehran Habibi MD Looking at Gene Mutations
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Heterogeneity: SABCS 2022 Adrian Lee PhD Highlighted Research in Transcriptomics
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Heterogeneity: SABCS 2022 Adrian Lee PhD Highlighted Research in Transcriptomics
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Heterogeneity: SABCS 2022 Adrian Lee PhD Highlighted Research in Transcriptomics
Heterogeneity: SABCS 2022 Adrian Lee PhD Highlighted Research in Transcriptomics
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Heterogeneity: SABCS 2022 Adrian Lee PhD Highlighted Research in Transcriptomics
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Heterogeneity: SABCS 2022 Adrian Lee PhD Highlighted Research in Transcriptomics
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PI3Kα: SABCS 2022 Axel Hoos STX-478 Xenograft Models Breast Cancer
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