The complications in blood and marrow transplantation can be serious with rapid onset, therefore ideal donor matching is crucial in minimizing complications. In this talk, Enric Carreras, MD, PhD, from the Hospital Clinic of Barcelona, Barcelona, Spain, outlines the process of donor selection for blood and marrow transplants and the variables to be considered in selecting ideal donors. This video was recorded at the 2018 European Society for Blood and Marrow Transplantation (EBMT) Annual Meeting in Lisbon, Portugal.