Saghi Ghaffari, MD, PhD of @MountSinaiNYC @sinaistemcell answers a way to enhance the potency of blood-forming stem cells, potentially opening a new approach for bone marrow transplant: what about human stem cells?
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Researchers at Mount Sinai have found a way to boost the potency of blood-forming stem cells, potentially opening the door to a new approach to bone marrow transplantation, according to a report published in Cell Stem Cell on February 27.
Blood-forming stem cells, known as hematopoietic stem cells (HSCs), are rare and seriously restrict bone marrow transplantation, which can treat many blood diseases and solid tumours. The Mount Sinai team reports that modulation of metabolic activity around lysosomes, the centers of storage and recycling within cells, can increase the potency of blood-forming stem cells in bone marrow transplantation by more than 90 times.