The outcomes of patients with post-myeloproliferative neoplasm acute myeloid leukemia (post-MPN AML) are poor, with no standard therapy. In this interview, Farhad Ravandi, MD, from the University of Texas MD Anderson Cancer Center, Houston, TX, provides an overview of the Phase I/II study (NCT02257138) of ruxolitinib plus decitabine in patients with post-MPN AML. He emphasizes that the interim results have demonstrated promising response rates in this subpopulation of patients, but will need further investigation to assess its safety and efficacy. This interview was recorded at the American Society of Hematology (ASH) 2017 Annual Meeting and Exposition in Atlanta, GA.
Ruxolitinib plus decitabine in post-MPN AML
