At the American Society of Hematology (ASH) 2015 Annual Meeting, John Gribben, MD, DSc and Stephan Stilgenbauer, MD discuss several topics related to chronic lymphocytic leukemia (CLL). The topics covered range from: ASH 2015 highlights; Bcl-2-targeted therapies; Resonate-2 clinical trial; implications and challenges of long-term therapy; venetoclax (ABT-199); combination therapies; and other related topics.