A massive Oxford meta-analysis they have completed has shown that adjuvant radiotherapy gives absolute benefits in terms of progression-free and overall- survival in women with breast cancer who have one, two, or three involved axillary lymph nodes clarifying a long-held uncertainty. Up to now four or more nodes has been a status known to benefit from R/T, while node-zero did not confer any benefit from R/T. The effect is surprisingly large and is just as strong among women who received either chemotherapy or endocrine therapy extending considerably the application of adjuvant radiotherapy.