The TroMBone trial (ISRCTN15704862), comparing radical prostatectomy with systemic therapy vs. systemic therapy alone in men with oligometastatic prostate cancer, is currently underway in the UK, with results eagerly anticipated. Here, Prasanna Sooriakumaran, PhD, MRCS, FRCS (Urol), from University College London, London, UK, discusses the randomized control trial. Initially, patients were apprehensive; however, as chemotherapy was offered prior to surgery, trial participation increased. This video was recorded at the UK Oncology Forum (OF) 2018, held in Liverpool, UK.