William Smith, MD of Mount Sinai describes the effect of radiation therapy on the objective response and outcomes with nivolumab for hepatocellular carcinoma.
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Among patients with unresectable hepatocellular carcinoma who received combination upfront RT and nivolumab, we found the objective response rate (as determined by mRECIST criteria) to be 35%, substantially increased from historical controls, suggesting that this approach may increase the proportion of patients that would benefit from immune checkpoint inhibition.
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