In chronic lymphocytic leukemia (CLL), treatment is often delayed because patients develop infections. Florence Cymbalista, PhD, from the Hôpital Avicenne, Bobigny, France, presented results at the 23rd Congress of the European Hematology Association (EHA) 2018, held in Stockholm, Sweden, from a study investigating these patients. She found, using bronchoalveolar lavage and fibroscopy, that the patients who developed infections displayed pulmonary localizations of CLL. She discusses the potential for detecting which patients are at risk from infection, and the importance of treating those patients early to prevent further pulmonary infiltration of CLL.