CAR T-cell agents, as a breakthrough therapy, have their challenges. Here, Rose Ellard from Kings College Hospital NHS Foundation Trust, London, UK, outlines the importance of formal training in managing the side effects of CAR T-cell therapy. She also highlights the need for networking between healthcare professionals on the frontline in an area that is still being learned about. This video was recorded at the 2018 European Society for Blood and Marrow Transplantation (EBMT) Annual Meeting in Lisbon, Portugal.