Alexis Combes, Ph.D., Director of Disease to Biology Colab at UCSF, Assistant professor department of pathology speaks about Sorting Cancers by "Immune Archetypes" Represents Potential New Approach to Developing Precision Immunotherapies.
Link to Article:
https://medicalxpress.com/news/2022-01-cancers-immune-archetypes-potential-approach.html
Link to Study:
https://authors.elsevier.com/c/1eJiWL7PXf0Zu
Synopsis
Cancers differ significantly in terms of origin tissue, driver mutations, and other aspects of the surrounding tissue. Individual tumors are likely to engage common immune system patterns, or “archetypes,” to create prototype non-destructive tumor immune microenvironments (TMEs) and modulate tumor-targeting. The Immunoprofiler Initiative (IPI) at the University of California, San Francisco (UCSF) evaluated 364 unique tumors across 12 cancer types using standardized techniques to discover the prevailing immune system archetypes. Flow cytometry and transcriptome data from cell sub-compartments were computationally clustered to reveal prevalent patterns of immune makeup across malignancies. These archetypes were significant because they distinguished malignancies based on distinct immune and tumor gene expression patterns. They also divided well-established tumor biology classifications. The IPI resource offers a framework for seeing cancer immunity as a collection of prominent immune organization patterns, as well as a reasonable method for learning how to modify these patterns to optimize therapy.