Dr. Erin Murphy, MD of Cleveland Clinic explains the phase I dose escalation study for neoadjuvant radiosurgery for large brain metastases.
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Preoperative (neoadjuvant) stereotactic radiosurgery (SRS) with dose escalation followed by surgical resection for brain metastases > 2 cm yielded local control comparable to that with postoperative SRS or whole-brain radiation therapy (WBRT) รขโฌโ with the benefits of acceptable acute toxicity and a low incidence of leptomeningeal disease.
These preliminary findings from a Cleveland Clinic prospective phase 1/2 clinical trial were presented Sept. 15 at the 2019 annual meeting of the American Society for Radiation Oncology (ASTRO).
รขโฌลSo far we have seen excellent results with radiation doses higher than the current SRS standards,รขโฌย says lead investigatorรย Erin Murphy, MD, a radiation oncologist in Cleveland Clinicรขโฌโขs Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center. รขโฌลIf findings continue to be positive, we anticipate that new standards can be adopted to safely save more patients from recurring disease.รขโฌย
Read the rest here:รย https://consultqd.clevelandclinic.org/high-dose-neoadjuvant-radiosurgery-for-brain-metastases-appears-safe-effective-in-early-results-from-phase-1-2-study/