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Home » Page 31

Novel ALL treatment strategies: inotuzumab ozogamicin

Acute Lymphoblastic Leukemia 1 Min Read

Over the past year, several exciting new agents for the treatment of acute lymphoblastic leukemia (ALL) have been approved. In…

Novel ALL treatment strategies: blinatumomab

Acute Lymphoblastic Leukemia 1 Min Read

There have recently been a number of major drug approvals for the treatment of acute lymphoblastic leukemia (ALL). One such…

Understanding the mechanisms of venetoclax and ibrutinib resistance

Acute Lymphoblastic Leukemia 1 Min Read

We need to understand the mechanisms of drug resistance in order to prevent it, in addition to informing subsequent treatment…

Durvalumab (Imfinzi) FDA Approved for Stage III NSCLC: Should It Become Standard of Care Without Overall Survival Benefit Demonstrated? (BMIC-024)

Acute Lymphoblastic Leukemia 1 Min Read

Dr. Jack West reviews key results of the PACIFIC trial of the immunotherapy agent durvalumab (Imfinzi) vs. placebo in stage…

Rationale and results behind the use of breakthrough therapy-designated E-selectin antagonist for AML

Acute Lymphoblastic Leukemia 1 Min Read

The binding of E-selectin to leukemic cells has been shown to promote cell survival and chemotherapy resistance in acute myeloid…

Complete remission seen in advanced systemic mastocytosis with avaritinib

Acute Lymphoblastic Leukemia 1 Min Read

The majority of patients with advanced systemic mastocytosis (AdvSM) exhibit D816V mutations of the KIT gene, which presents a promising…

WhatÂ’s next for inotuzumab ozogamicin in ALL?

Acute Lymphoblastic Leukemia 1 Min Read

The anti-CD22 antibody-drug conjugate inotuzumab ozogamicin was approved for the treatment of B-cell precursor acute lymphoblastic leukemia (ALL), the most…

A next-generation CD33-directed ADC for AML

Acute Lymphoblastic Leukemia 1 Min Read

Next-generation antibody-drug conjugates (ADCs) are demonstrating improved safety and tolerability compared with their predecessors. Speaking from the American Society of…

The evolving role of the Clinical Research Nurse and the Clinical Nurse Specialist in clinical trials

Acute Lymphoblastic Leukemia 1 Min Read

With the increasing complexity of clinical trials, the role of the Clinical Research Nurse (CRN) and the Clinical Nurse Specialist…

Nurses and recognizing each otherÂ’s work pressures

Acute Lymphoblastic Leukemia 1 Min Read

Staff within the NHS are very busy and work pressures can result in less time for communication between nurses. In…

The nursesÂ’ role in improving the clinical trial experience of patients

Acute Lymphoblastic Leukemia 1 Min Read

What can be done to improve the experience of clinical trials for patients who participate? In this interview, recorded at…

Meeting in the box: working out the best practice strategies for HCPs and patients

Acute Lymphoblastic Leukemia 1 Min Read

Different NHS trusts work in different ways; what could be considered the best practice in one trust may not be…

New therapeutic targets in CLL: ROR1

Acute Lymphoblastic Leukemia 1 Min Read

The identification of novel therapeutic targets is essential for the improved treatment of hematological cancer, particularly due to the development…

CAR T-cells for CLL: ibrutinib pre-treatment, T-cell quality and future predictions

Acute Lymphoblastic Leukemia 1 Min Read

We know that CAR T-cell therapy is effective in the treatment of chronic lymphocytic leukemia (CLL); however, a current limitation…

Cessation of venetoclax and remaining in remission from CLL?

Acute Lymphoblastic Leukemia 1 Min Read

There is not a large amount of data available to allow clinicians to determine whether patients should remain on or…

Pembrolizumab: defining standards of care in urothelial cancer

Acute Lymphoblastic Leukemia 1 Min Read

Following the completion of the initial stages of the KEYNOTE-045 trial of pembrolizumab vs. the standard care for advanced urothelial…

TKI and checkpoint inhibitor combinations for kidney cancer: the IMmotion151 trial

Acute Lymphoblastic Leukemia 1 Min Read

The current standard of care for frontline kidney cancer is tyrosine kinase inhibitor (TKI) treatment. Now there are a host…

Promising POUT: perioperative chemotherapy for upper tract urothelial cancer

Acute Lymphoblastic Leukemia 1 Min Read

The UK was well represented at the Genitourinary Cancers Symposium 2018, held in San Francisco, CA. In this video, Robert…

What does the 2-year follow-up tell us about the use of pembrolizumab for advanced bladder cancer?

Acute Lymphoblastic Leukemia 1 Min Read

Long-term follow-up data is the real determinant of the efficacy of novel therapies. Here, Robert Jones, PhD, of the University…

Head-to-head: tolerability of enzalutamide vs. abiraterone acetate for metastatic CRPC

Acute Lymphoblastic Leukemia 1 Min Read

The approval of enzalutamide for the treatment of metastatic castration-resistant prostate cancer (mCRPC) provided an important life-extending drug. Now the…

Differentiating aggressive vs. non-aggressive prostate cancer: the MiCheck GPC1 biomarker test

Acute Lymphoblastic Leukemia 1 Min Read

The addition of a new prostate cancer diagnostic test to inform clinicians and patients prior to the decision to biopsy…

How will new NSAAs impact clinical practice in prostate cancer?

Acute Lymphoblastic Leukemia 1 Min Read

Previously, patients with nonmetastatic castration-resistant prostate cancer (nmCRPRC) and the clinicians treating them had no therapeutic options to delay disease…

Live long and PROSPER: enzalutamide for nmCRPC

Acute Lymphoblastic Leukemia 1 Min Read

There has previously been no approved treatment for nonmetastatic castration-resistant prostate cancer (nmCRPC), due to a lack of evidence that…

Supporting young hematology researchers: training programs offered by EHA and ASH

Acute Lymphoblastic Leukemia 1 Min Read

This interview provides an exciting insight into the Translational Research Training in Hematology (TRTH) and the Clinical Research Training in…

Novel methods to assess the effectiveness of chemotherapy in AML patients: MRD

Acute Lymphoblastic Leukemia 1 Min Read

It is extremely important to assess the long-term effects of chemotherapy in patients with acute myeloid leukemia (AML); however, with…

Randomized Phase III Trial of Atezolizumab + Bevacizumab The combination therapy proved efficacious, progression-free survival by PD-L1 group

Acute Lymphoblastic Leukemia 1 Min Read

Aly-Khan Lalani, MD from Dana-Farber Cancer Institute discusses the Randomized Phase III Trial of Atezolizumab + Bevacizumab The combination therapy…

Microbiome Effects of Antibodies Can Linger for Up to 60 Days Push a start date to allow time between antibiotic use and immunotherapy

Acute Lymphoblastic Leukemia 1 Min Read

Aly-Khan Lalani, MD from Dana-Farber Cancer Institute discusses the Microbiome Effects of Antibodies Can Linger for Up to 60 Days…

Using Microbiome Transplantation or FMT for RCC They should still benefit from their given immunotherapy with additional supplements

Acute Lymphoblastic Leukemia 1 Min Read

Aly-Khan Lalani, MD from Dana-Farber Cancer Institute discusses tUsing Microbiome Transplantation or FMT for RCC They should still benefit from…

Systemic Therapy in Metastatic Renal Cell Carcinoma Antibiotic use does affect outcomes in patients

Acute Lymphoblastic Leukemia 1 Min Read

Aly-Khan Lalani, MD from Dana-Farber Cancer Institute discusses the Systemic Therapy in Metastatic Renal Cell Carcinoma Antibiotic use does affect…

Exciting randomized trials for mesothelioma: checkpoint inhibitor monotherapies and vinorelbine

Acute Lymphoblastic Leukemia 1 Min Read

Only one treatment for malignant mesothelioma has been approved since 2003 and rates of the disease are rising worldwide; thus,…

Cutting-edge UK trials for mesothelioma: double immuno, arginine depletion and molecular profiling

Acute Lymphoblastic Leukemia 1 Min Read

There is currently an array of exciting clinical trials for mesothelioma, investigating cutting-edge treatments in large patient groups. Here, Dean…

Mesothelioma biology: key genes and therapeutic targeting

Acute Lymphoblastic Leukemia 1 Min Read

There has been a vast increase in our understanding of the pathology of mesothelioma in the past 5 years, which…

Mesothelioma: the key unanswered question

Acute Lymphoblastic Leukemia 1 Min Read

Mesothelioma cases are on the rise, in both developed and developing countries. Thus, increased understanding of the underlying mechanisms of…

An MRI-based approach to prostate cancer diagnosis: a urologistÂ’s stance in the debate

Acute Lymphoblastic Leukemia 1 Min Read

The first study illustrating the potential of MRI in the diagnosis of prostate cancer was published in 2006. Although there…

Challenges for prostate cancer: overdiagnosis and unnecessary treatment

Acute Lymphoblastic Leukemia 1 Min Read

The current diagnostic methods for prostate cancer are not always as reliable or accurate as they could be, leading to…

Is delayed diagnosis in the UK to blame for poorer cancer outcomes?

Acute Lymphoblastic Leukemia 1 Min Read

Recent news reports have identified poorer outcomes in cancer patients from the UK compared with those in certain other European…

MRI-based prostate cancer diagnosis: economic and logistical considerations

Acute Lymphoblastic Leukemia 1 Min Read

The take-home message from the 2018 Genitourinary Cancers Symposium, in San Francisco, CA, on MRI for prostate cancer diagnosis was…

MRI and MRI-directed biopsies for the diagnosis of prostate cancer

Acute Lymphoblastic Leukemia 1 Min Read

The utilization of MRI for the diagnosis of prostate cancer in men at risk is relatively new. In this interview,…

Teamwork between urologists and oncologists in the UK

Acute Lymphoblastic Leukemia 1 Min Read

Current practice in the UK requires urologists to refer patients with urological cancer to oncologists for treatment. In this interview,…

This is SPARTAN! Apalutamide treatment for nmCRPC

Acute Lymphoblastic Leukemia 1 Min Read

Highly anticipated data from the Phase III SPARTAN study (NCT01946204), which investigated apalutamide for nonmetastatic castration-resistant prostate cancer (nmCRPC), was…

Straightforward study design: SPARTAN trial of apalutamide for nmCRPC

Acute Lymphoblastic Leukemia 1 Min Read

There has previously been no effective treatment for nonmetastatic castration-resistant prostate cancer (nmCRPC). Now there are several exciting late-phase clinical…

SPARTAN vs. PROSPER: apalutamide or enzalutamide for nmCRPC?

Acute Lymphoblastic Leukemia 1 Min Read

With exciting data from the Phase III SPARTAN (NCT01946204) and PROSPER (NCT02003924) trials of apalutamide and enzalutamide, respectively, for the…

How will the results of the SPARTAN study impact US clinical practice in prostate cancer?

Acute Lymphoblastic Leukemia 1 Min Read

The emergence of an effective treatment for nonmetastatic castration-resistant prostate cancer (nmCRPC) is likely to have a paradigm-changing effect on…

Nonmetastatic CRPC: meeting an unmet need

Acute Lymphoblastic Leukemia 1 Min Read

Nonmetastatic castration-resistant prostate cancer (nmCRPC) is a disease which had no FDA-approved treatment. Following the completion of the Phase III…

How do we select the urothelial carcinoma patients who will benefit from checkpoint inhibitors?

Acute Lymphoblastic Leukemia 1 Min Read

With the emergence of five novel immune checkpoint inhibitors for the treatment of urothelial carcinoma, the key question now arising…

PD-L1 and TMB as biomarkers in the IMvigor211 trial of atezolizumab vs. chemo for bladder cancer

Acute Lymphoblastic Leukemia 1 Min Read

A highly anticipated topic at the 2018 Genitourinary Cancers Symposium, held in San Francisco, CA, was immune checkpoint inhibitor data…

Will immune checkpoint inhibitors become the new standard of care for urothelial cancer?

Acute Lymphoblastic Leukemia 1 Min Read

Immune checkpoint inhibitors for urothelial carcinoma in the relapsed/refractory setting have already been approved and are superseding standard chemotherapy. Now,…

Immune checkpoint inhibitors for urothelial carcinoma: the current landscape

Acute Lymphoblastic Leukemia 1 Min Read

Novel immune checkpoint inhibitors that are entering the clinic are changing the way in which we treat metastatic urothelial carcinoma,…

MRD studies in ALL and AML

Acute Lymphoblastic Leukemia 1 Min Read

Minimal residual disease (MRD) monitoring is a promising and controversial topic, with its increasing use in clinical trials being followed…

Current management of Ph-positive ALL

Acute Lymphoblastic Leukemia 1 Min Read

There was exciting new trial data for the management of Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL) from the American Society…

Decitabine dosing regimens in older AML patients: 5-day vs. 10-day, is there a difference?

Acute Lymphoblastic Leukemia 1 Min Read

Older acute myeloid leukemia (AML) patients are not typically given intensive cytotoxic chemotherapy due to their fragility and comorbidities. Decitabine…

Ruxolitinib plus decitabine in post-MPN AML

Acute Lymphoblastic Leukemia 1 Min Read

The outcomes of patients with post-myeloproliferative neoplasm acute myeloid leukemia (post-MPN AML) are poor, with no standard therapy. In this…

Triple therapy including nivolumab for newly diagnosed AML

Acute Lymphoblastic Leukemia 1 Min Read

Farhad Ravandi, MD, from the University of Texas MD Anderson Cancer Center, Houston, TX, provides an overview of the pilot…

Multiple myeloma highlights at ASH 2017

Acute Lymphoblastic Leukemia 1 Min Read

The American Society of Hematology (ASH) 2017 Annual Meeting and Exposition in Atlanta, GA, was an exciting one for multiple…

Myeloma XI trial: impact of MRD on treatment response in MM

Acute Lymphoblastic Leukemia 1 Min Read

Minimal residual disease (MRD) is the major cause of relapse in multiple myeloma (MM), and measurements of its level can…

Myeloma XI trial: lenalidomide maintenance therapy for multiple myeloma

Acute Lymphoblastic Leukemia 1 Min Read

At the American Society of Hematology (ASH) 2017 Annual Meeting and Exposition in Atlanta, GA, Graham Jackson, FRCP, FRCPath, MD,…

Copanlisib for relapsed/refractory NHL: results of the CHRONOS-1 study

Acute Lymphoblastic Leukemia 1 Min Read

Copanlisib is a novel PI3K inhibitor, targeting both PI3K-? and PI3K-? isoforms in malignant B-cells. It was granted FDA approval…

Ibrutinib combination therapy in CLL: overview of the data so far

Acute Lymphoblastic Leukemia 1 Min Read

Ibrutinib combination therapy in an exciting therapeutic area with great potential. Many recent and ongoing studies are seeking to identify…

MURANO study: exciting times in CLL

Acute Lymphoblastic Leukemia 1 Min Read

Data from the Phase III MURANO study (NCT02005471) in relapsed/refractory chronic lymphocytic leukemia (CLL) was highly anticipated at the American…

PEP-C for lymphoma palliative care: a regional experience in the UK

Acute Lymphoblastic Leukemia 1 Min Read

Treating lymphoma patients in the relapsed/refractory setting often proves a challenge for physicians. PEP-C (prednisolone, etoposide, procarbazine and cyclophosphamide) is…

ABVD vs. escBEACOPP in HL: a 10-year study

Acute Lymphoblastic Leukemia 1 Min Read

In the UK, escalated BEACOPP (escBEACOPP) was introduced as an alternative to ABVD for the treatment of advanced-stage Hodgkin lymphoma…

Nurse-led rapid access lung cancer clinic in Wales: a case study

Acute Lymphoblastic Leukemia 1 Min Read

An exciting new nurse-led rapid access lung cancer clinic has been started in Ceredigion, Wales. Here, the Clinical Nurse Specialist…

Aiming for the NOLCP in Wales and HCP collaboration

Acute Lymphoblastic Leukemia 1 Min Read

This years British Thoracic Oncology Group (BTOG) Annual Conference 2018, held in Dublin, Ireland, presented a range of exciting data,…

Next steps for the nurse-led rapid access lung cancer clinic in Wales

Acute Lymphoblastic Leukemia 1 Min Read

The role of the nurse in the management and care of patients with cancer is essential one, which is evolving…

Democratizing surgery: bringing robotic surgery to all surgeons

Acute Lymphoblastic Leukemia 1 Min Read

Robotic surgery equipment is notoriously expensive, limiting the number of hospitals and surgeons who can utilize this beneficial technology. In…

New robotic-assisted thoracic surgery platforms: companies in competition

Acute Lymphoblastic Leukemia 1 Min Read

Where there was previously one primary manufacturer for robotic-assisted surgery machinery, there are now several newcomers on the block. Speaking…

Minimally invasive thoracic surgery trials: VIOLET and robotic-assisted surgery data

Acute Lymphoblastic Leukemia 1 Min Read

Despite some forms of minimally invasive surgery being performed for some time, we are still lacking the analytical evidence that…

Robotic-assisted thoracic surgery: the future of lung cancer surgery?

Acute Lymphoblastic Leukemia 1 Min Read

Robotic-assisted thoracic surgery can be combined with other techniques and utilized for a wide range of procedures. Here, Joel Dunning,…

Robotic-assisted thoracic surgery: debunking the misconceptions

Acute Lymphoblastic Leukemia 1 Min Read

Robotic-assisted surgery is an exciting, innovative area, which is growing and becoming more widespread. Here, Joel Dunning, PhD, FRCS, of…

A "chemo-sparing" MRD-driven strategy for CLL

Acute Lymphoblastic Leukemia 1 Min Read

This is an exciting time for chronic lymphocytic leukemia (CLL) research, with the possibility of chemotherapy-free treatment approaches. In this…

TP53 mutations in CLL: a large retrospective analysis

Acute Lymphoblastic Leukemia 1 Min Read

Little is known about TP53 mutations and their association with adverse prognosis and chemotherapy resistance in chronic lymphocytic leukemia (CLL).…

Immune & Combination Therapies Will be Important for Years Because of tougher, older, and resistant patient populations

Acute Lymphoblastic Leukemia 1 Min Read

Dr. Ann Eapen Division of Hematology/Oncology: UC Irvine discusses Immune & Combination Therapies Will be Important for Years Because of…

Adverse Effects of Venetoclax and Ibrutinib Only 1 in 50 Patients had Tumor Lysis Syndrome

Acute Lymphoblastic Leukemia 1 Min Read

Dr. Ann Eapen Division of Hematology/Oncology: UC Irvine discusses Adverse Effects of Venetoclax and Ibrutinib Only 1 in 50 Patients…

Drugs to Use if One has Cancer or Clots Rivaroxaban, Apixaban, Edoxaban are effective oral drugs

Acute Lymphoblastic Leukemia 1 Min Read

Kanwarpal Kahlon, MD, from Ronald Reagan UCLA Medical Center talks about Drugs to Use if One has Cancer or Clots…

CLARITY Trial Limitations; No Control Group Extrapolated onto the FLAIR Trial Studying Group Combinations

Acute Lymphoblastic Leukemia 1 Min Read

Dr. Ann Eapen Division of Hematology/Oncology: UC Irvine discusses CLARITY Trial Limitations; No Control Group Extrapolated onto the FLAIR Trial…

Diagnostic Criteria for Thrombotic Thrombocytopenic Purpura One needs less than 10of ADAMTS13 activity

Acute Lymphoblastic Leukemia 1 Min Read

Kanwarpal Kahlon, MD, from Ronald Reagan UCLA Medical Center talks Diagnostic Criteria for Thrombotic Thrombocytopenic Purpura One needs less than…

Positive Data for RR-CLL Patients Able to see MRD Negativity at month 6

Acute Lymphoblastic Leukemia 1 Min Read

Dr. Ann Eapen Division of Hematology/Oncology: UC Irvine discusses Positive Data for RR-CLL Patients Able to see MRD Negativity at…

Highlights from MDS and Nonmalignant Hematology New drugs for MDS: Rigosertib, Luspatercept, Ibrutnib

Acute Lymphoblastic Leukemia 1 Min Read

Kanwarpal Kahlon, MD, from Ronald Reagan UCLA Medical Center talks Highlights from MDS and Nonmalignant Hematology New drugs for MDS:…

The CLARITY Trial Lead by Dr. Hillmen Feasibility study that looked at efficacy of Ibrutnib and Venetolax in RR-CLL

Acute Lymphoblastic Leukemia 1 Min Read

Dr. Ann Eapen Division of Hematology/Oncology: UC Irvine discusses The CLARITY Trial Lead by Dr. Hillmen Feasibility study that looked…

JAK Inhibitors are a Central Theme in MPN Lots of JAK Inhibitors being tested in clinical trials

Acute Lymphoblastic Leukemia 1 Min Read

Angela Fleischman MD PhD UC Irvine discusses JAK Inhibitors are a Central Theme in MPN Lots of JAK Inhibitors being…

Rituximab Maintenance for Follicular Lymphoma CAR-T Trial salvages Primary, Refractory, or those who failed initial therapy

Acute Lymphoblastic Leukemia 1 Min Read

Elizabeth Brém, MD – HS Clinical Assistant Professor Chao Comprehensive Cancer Center discusses Rituximab Maintenance for Follicular Lymphoma CAR-T Trial…

Managing Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutations associated with Myeloid Malignancies; DNMT3A, TET2, JACK2-V617F

Acute Lymphoblastic Leukemia 1 Min Read

Angela Fleischman MD PhD UC Irvine discusses Disease Managing Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutations associated with Myeloid Malignancies;…

Echelon-1 Data Showed Modified Progression Free Survival Increased toxicity may not be worth a few points in overall survival

Acute Lymphoblastic Leukemia 1 Min Read

Elizabeth Brém, MD – HS Clinical Assistant Professor Chao Comprehensive Cancer Center discusses Echelon-1 Data Showed Modified Progression Free Survival…

Distinguish Between Clonal Disorder & a Germ-Line Mutation Clonal disorder is a hematologic malignancy; risk of Myelofibrosis

Acute Lymphoblastic Leukemia 1 Min Read

Angela Fleischman MD PhD UC Irvine discusses Distinguishing Between Clonal Disorder & a Germ-Line Mutation Clonal disorder is a hematologic…

Efficacy & Toxicity of CAR-T Trials and The Echelon-1 Trial Brentuximab Vedotin + AVD or ABVD

Acute Lymphoblastic Leukemia 1 Min Read

Elizabeth Brém, MD – HS Clinical Assistant Professor Chao Comprehensive Cancer Center discusses Efficacy & Toxicity of CAR-T Trials and…

Preventing Progress of MPN Presently this area is limited and needs to be focused on

Acute Lymphoblastic Leukemia 1 Min Read

Angela Fleischman MD PhD UC Irvine discusses Preventing Progress of MPN Presently this area is limited and needs to be…

Update on PRIMA Study Progression Free Survival from patients with Rituximab Maintenance

Acute Lymphoblastic Leukemia 1 Min Read

Elizabeth Brém, MD – HS Clinical Assistant Professor Chao Comprehensive Cancer Center discusses updates on PRIMA Study Progression Free Survival…

MPN (Myeloproliferative Neoplasm) & CHIP New phenomenon in aging individuals with mutations associated with MM

Acute Lymphoblastic Leukemia 1 Min Read

Angela Fleischman MD PhD UC Irvine discusses MPN (Myeloproliferative Neoplasm) & CHIP New phenomenon in aging individuals with mutations associated…

CAR-T Therapies will Dominate in 2018 Next Generation BTK Inhibitor data is still early

Acute Lymphoblastic Leukemia 1 Min Read

Elizabeth Brém, MD – HS Clinical Assistant Professor Chao Comprehensive Cancer Center discusses how CAR-T Therapies will Dominate in 2018…

Disease Modifying Agents on the Horizon for MPN Hope to impact, intervene, & change course of disease progression early

Acute Lymphoblastic Leukemia 1 Min Read

Angela Fleischman MD PhD UC Irvine discusses Disease Modifying Agents on the Horizon for MPN Hope to impact, intervene, &…

Retrospective Analysis Looked At Rituximab Maintenance Patients achieving partial remission benefited most from rituximab maintenance

Acute Lymphoblastic Leukemia 1 Min Read

Elizabeth Brém, MD – HS Clinical Assistant Professor Chao Comprehensive Cancer Center discusses updates Retrospective Analysis Looked At Rituximab Maintenance…

Whiteboard Video: The Management of Adverse Events of Tyrosine Kinase Inhibitors

Acute Lymphoblastic Leukemia 1 Min Read

Tyrosine kinase inhibitors (TKIs) are orally active, small molecules that exhibit antitumor activity by targeting enzymes that play a critical…

Whiteboard Video: The Mechanisms of Action of Tyrosine Kinase Inhibitors

Acute Lymphoblastic Leukemia 1 Min Read

Tyrosine kinase inhibitors (TKIs) are orally active, small molecules that exhibit antitumor activity by targeting enzymes that play a critical…

Whiteboard Video: The Epidemiology of Hepatocellular Carcinoma and Current Standard of Care

Acute Lymphoblastic Leukemia 1 Min Read

Tyrosine kinase inhibitors (TKIs) are orally active, small molecules that exhibit antitumor activity by targeting enzymes that play a critical…

Velocity Vlog: Role of TKIs in Hepatocellular Carcinoma – Recent Updates

Acute Lymphoblastic Leukemia 1 Min Read

In this Velocity Vlog activity, Dr. Richard S. Finn of the UCLA Geffen School of Medicine, provides a brief overview…

Novel agent filanesib combination therapy for R/R multiple myeloma

Acute Lymphoblastic Leukemia 1 Min Read

Filanesib is a novel agent that has previously shown clinical activity in pretreated multiple myeloma (MM) patients. In this interview,…

Pembrolizumab consolidation therapy in multiple myeloma

Acute Lymphoblastic Leukemia 1 Min Read

Enrique Ocio, MD, PhD, from University Hospital of Salamanca, Salamanca, Spain, gives us an overview of the GEM-Pembresid trial (NCT02636010),…

VCDI for multiple myeloma: an update

Acute Lymphoblastic Leukemia 1 Min Read

VCD (bortezomib, cyclophosphamide and dexamethasone) is an effective chemotherapy combination commonly used for the treatment of newly diagnosed multiple myeloma…

Results of the MURANO study for CLL

Acute Lymphoblastic Leukemia 1 Min Read

The results of the Phase III MURANO trial (NCT02005471) were important to address a number of unanswered questions surrounding the…

ASH 2017: CLL combination therapy highlights

Acute Lymphoblastic Leukemia 1 Min Read

Now that hematological oncologists have an arsenal of novel single agents, the natural next step is to determine the best…

Lung cancer immunotherapy test standardization: the Blueprint PD-L1 IHC Assay Comparison Project

Acute Lymphoblastic Leukemia 1 Min Read

With the increasing use of immunotherapy, methods of response testing need to be rigorous and comparable. However, as explained here…

Unanswered questions in lung cancer immunotherapy

Acute Lymphoblastic Leukemia 1 Min Read

There are many areas of uncertainty surround immunotherapy, which require further exploration in the coming years. Speaking from the British…

Hot topic: optimal immunotherapy combinations for lung cancer

Acute Lymphoblastic Leukemia 1 Min Read

Now that there is a range of immunotherapies available, the next frontier to explore is immunotherapy combination regimens. In this…

Lung cancer immunotherapy response testing: PDL-1, TMB or an alternative?

Acute Lymphoblastic Leukemia 1 Min Read

At the British Thoracic Oncology Group (BTOG) Annual Conference 2018, held in Dublin, Ireland, Fred Hirsch, MD, PhD, of University…

Tumor mutational burden (TMB): a predictive biomarker for lung cancer immunotherapy response

Acute Lymphoblastic Leukemia 1 Min Read

Tumor mutational burden (TMB) is emerging as a promising predictive biomarker for lung cancer immunotherapy response. Here, Fred Hirsch, MD,…

Immunotherapy: will we reach a point where we can curatively treat advanced NSCLC?

Acute Lymphoblastic Leukemia 1 Min Read

With the great promise that immunotherapy holds, there are hopes that it will revolutionize the treatment of lung cancer. Here,…

Lung cancer immunotherapy trial data to look forward to in 2018

Acute Lymphoblastic Leukemia 1 Min Read

With exciting data for immuno-oncology in lung cancer, there is much anticipation for what 2018 holds. In this interview, Solange…

Paradigm-changing immunotherapy for advanced NSCLC: the PACIFIC and beyond

Acute Lymphoblastic Leukemia 1 Min Read

Immunotherapy is an exciting area for lung cancer, with numerous possibilities and game-changing potential. Speaking from the British Thoracic Oncology…

The role of immunotherapy in the radical treatment of NSCLC: where are we headed?

Acute Lymphoblastic Leukemia 1 Min Read

After many negative trial results for non-small cell lung cancer (NSCLC) therapies for some time, the field is now evolving…

ASH 2017: combination therapy for CLL highlights

Acute Lymphoblastic Leukemia 1 Min Read

Numerous trials worldwide are now focusing on combination therapy for relapsed/refractory chronic lymphocytic leukemia (CLL). In this interview, Barbara Eichhorst,…

Impacts of the MURANO study for future CLL treatment

Acute Lymphoblastic Leukemia 1 Min Read

Data from the Phase III MURANO study (NCT02005471) is a hot topic in the field of hematological oncology. The study…

"Sequential triple-T" therapy for CLL

Acute Lymphoblastic Leukemia 1 Min Read

Sequential triple-T therapy is a regimen consisting of tailored and targeted treatment aiming for total eradication of minimal residual disease…

Bendamustine plus rituximab vs. standard therapy for advanced CLL

Acute Lymphoblastic Leukemia 1 Min Read

Fludarabine, cyclophosphamide and rituximab (FCR) is the standard chemotherapy regimen used to treat chronic lymphocytic leukaemia (CLL). In this interview,…

Advancements in AML therapy at ASH 2017

Acute Lymphoblastic Leukemia 1 Min Read

Over the past 10 years, there has been a massive expansion in the number and classes of treatments available for…

IDH inhibition in AML therapy

Acute Lymphoblastic Leukemia 1 Min Read

The last 5-10 years has been a very exciting time for the treatment of myeloid malignancies, with great advances in…

Introduction & Individualizing Treatment for Your Patients with RRMM: Selecting Among the Available Options

Acute Lymphoblastic Leukemia 1 Min Read

Presented by Robert Z. Orlowski, MD, PhD; and Peter M. Voorhees, MD. Part 1 of 3 of a symposium recorded…

Optimal Strategies for the Identification and Management of Treatment-Related Adverse Events

Acute Lymphoblastic Leukemia 1 Min Read

Presented by Ajay K. Nooka, MD, MPH, FACP. Part 2 of 3 of a symposium recorded at an oncology specialty…

Improving Practice and Future Perspectives: Panel Discussion

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Presented by Ajay K. Nooka, MD, MPH, FACP; Robert Z. Orlowski, MD, PhD; and Peter M. Voorhees, MD. Part 3…

Novel CLL therapy highlights from ASH 2017

Acute Lymphoblastic Leukemia 1 Min Read

Data for non-chemotherapy-based treatments is increasing exponentially, with the presentations at the American Society of Hematology (ASH) 2017 Annual Meeting…

Checkpoint inhibitor/bispecific antibody combo: REGN2810 and REGN1979 in B-lymphoid malignancies

Acute Lymphoblastic Leukemia 1 Min Read

Immune checkpoint inhibitors and T-cell engaging bi-specific antibodies have shown promising activity against lymphoid malignancies. In this interview, Anthony Mato,…

Triple therapy for CLL: pembrolizumab, ublituximab and umbralisib

Acute Lymphoblastic Leukemia 1 Min Read

Data from recent studies indicate that PD-1 and PD-L1/PD-L2 mediate immune evasion in chronic lymphocytic leukemia (CLL), highlighting their importance…

Update MDS and Nonmalignant Heme

Acute Lymphoblastic Leukemia 1 Min Read

Kanwarpal Kahlon, MD, from Ronald Reagan UCLA Medical Center talks about updates on Myelodysplastic syndrome and nonmalignant hemetology at MOASCs…

Updates in Myeloproliferative Neoplasm

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Angela Fleischman, MD, from UC Irvine joins us at MOASCs Spotlight On Hematology in Huntington Beach to discusses the updates…

Highlights of ASH 2017: Acute Myeloid Leukemia

Acute Lymphoblastic Leukemia 1 Min Read

Deepa Jeyakumar, MD, from UC Irvine Health discusses the Acute myeloid leukemia highlights from ASH 2017 at MOASCs Spotlight On®…

Highlights of ASH 2017 Lymphomas

Acute Lymphoblastic Leukemia 1 Min Read

Elizabeth Brém, MD, from The Chao Comprehensive Cancer Center joins us at MOASCs Spotlight On® Hematology in Huntington Beach to…

American Society Of Hematology Multiple Myeloma Updates

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Amrita Krishnan MD FACP of The Judy and Bernard Briskin Center for Multiple Myeloma Research discusses the updates at ASH…

Initial Results of Ibrutinib Plus Venetoclax in Relapsed Refractory CLL

Acute Lymphoblastic Leukemia 1 Min Read

Ann Eapen, MD, from UC-Irvine Department of Hematology and Oncology is presenting the CLARITY Trial (Bloodwise TAP Study) which looks…

Initial Results of the Phase 2 Treatment Naive Cohort in a Phase 1b/2 Study of Obinutuzumab, Ibrutinib, and Venetoclax in CLL

Acute Lymphoblastic Leukemia 1 Min Read

Miguel Risco, MD, from UC-Irvine Department of Hematology and Oncology joins us at MOASCs Spotlight On® Hematology in Huntington Beach…

The Role of CPX-351? – Used as an outpatient for newly-diagnosed AML

Acute Lymphoblastic Leukemia 1 Min Read

Deepa Jeyakumar, MD, from UC Irvine Health talks about trying to understand the role of CPX-351 and if can be…

Safety of Chronic Lymphocytic Leukemia Combination Therapy – Fair Number of Hematologic & Non-Hematologic Adverse Effects

Acute Lymphoblastic Leukemia 1 Min Read

Miguel Risco, MD, from UC-Irvine Department of Hematology and Oncology joins us at MOASCs Spotlight On® Hematology in Huntington Beach…

Toxicities with IDH1 & IDH2 Inhibitors – IDH Differentiation Syndrome is a new side-effect

Acute Lymphoblastic Leukemia 1 Min Read

Deepa Jeyakumar, MD, from UC Irvine Health For Multiple Myeloma Research joins us at MOASCs Spotlight On® Hematology in Huntington…

Strategies for Treating Relapsed Myeloma – Daratumumab with IMiDs, Venetoclax, Transplants

Acute Lymphoblastic Leukemia 1 Min Read

Amrita Krishnan, MD, from The Judy and Bernard Briskin Center For Multiple Myeloma Research joins us at MOASCs Spotlight On®…

Trials in Combination Therapy for CLL – Phase 2 Trial results with Obinutuzumab, Ibrutunib, & Venetoclax

Acute Lymphoblastic Leukemia 1 Min Read

Miguel Risco, MD, from UC-Irvine Department of Hematology and Oncology joins us at MOASCs Spotlight On® Hematology in Huntington Beach…

Midostaurin is the 1st New and Approved AML Drug in a Long Time – For patients with FLT3 positive AML in the upfront setting

Acute Lymphoblastic Leukemia 1 Min Read

Deepa Jeyakumar, MD, from UC Irvine Health talks about, Midostaurin, the 1st new and approved AML drug in a long…

Tandem Transplantation in Multiple Myeloma – Phase 3 Trial showed patients had a progression free survival benefit

Acute Lymphoblastic Leukemia 1 Min Read

Amrita Krishnan, MD, from The Judy and Bernard Briskin Center For Multiple Myeloma Research joins us at MOASCs Spotlight On®…

Drugs to Use if One has Cancer or Clots – Rivaroxaban, Apixaban, Edoxaban are effective oral drugs

Acute Lymphoblastic Leukemia 1 Min Read

Kanwarpal Kahlon, MD, from Ronald Reagan UCLA Medical Center joins us at MOASCs Spotlight On® Hematology in Huntington Beach to…

IDH2 Inhibitor for AML is Effective with RR Disease – Differentiation syndrome is a worrying side-effect

Acute Lymphoblastic Leukemia 1 Min Read

Deepa Jeyakumar, MD, from UC Irvine Health discusses how IDH2 inhibitor for AML is effective with Relapsed Refractory disease and…

Bluebird Trial BCMA CAR-T on 24 Patients – Over half of patients getting complete remissions

Acute Lymphoblastic Leukemia 1 Min Read

Amrita Krishnan, MD, from The Judy and Bernard Briskin Center For Multiple Myeloma Research joins us at MOASCs Spotlight On®…

Diagnostic Criteria for Thrombotic Thrombocytopenic Purpura – One needs less than 10% of ADAMTS13 activity

Acute Lymphoblastic Leukemia 1 Min Read

Kanwarpal Kahlon, MD, from Ronald Reagan UCLA Medical Center talks about the diagnostic criteria for thrombotic thrombocytopenic purpura and how…

4 New Drugs for Acute Myeloid Leukemia – Midostaurin, Gemtuzumab, and updates in CPX-351

Acute Lymphoblastic Leukemia 1 Min Read

Deepa Jeyakumar, MD, from UC Irvine Health talks about 4 new drugs for acute myeloid leukemia including Midostaurin, Gemtuzumab, and…

Antibody Drug Conjugate Against BCMA – 60% Response Rate in Refractory Myeloma

Acute Lymphoblastic Leukemia 1 Min Read

Amrita Krishnan, MD, from The Judy and Bernard Briskin Center For Multiple Myeloma Research talks about the antibody drug conjugate…

Highlights from MDS and Nonmalignant Hematology – New drugs for MDS: Rigosertib, Luspatercept, Ibrutnib

Acute Lymphoblastic Leukemia 1 Min Read

Kanwarpal Kahlon, MD, from Ronald Reagan UCLA Medical Center talks about the highlights from Myelodysplastic Syndrome (MDS) and nonmalignant hematology…

Retrospective multicenter analysis of venetoclax-treated CLL patients

Acute Lymphoblastic Leukemia 1 Min Read

Venetoclax is approved for the treatment of relapsed/refractory del17p chronic lymphocytic leukemia (CLL) and has shown activity in patients following…

Front-line use of ibrutinib for CLL in a real-world setting

Acute Lymphoblastic Leukemia 1 Min Read

Ibrutinib is approved for all lines of therapy in chronic lymphocytic leukemia (CLL); however, front-line ibrutinib studies have primarily enrolled…

Targeted medicine for ALK-mutated NSCLC

Acute Lymphoblastic Leukemia 1 Min Read

The rapidly changing landscape of NSCLC treatment has drastically improved outcomes for patients. In this interview, Yvonne Summers, BSc, MB…

The changing landscape of NSCLC diagnosis, monitoring and treatment

Acute Lymphoblastic Leukemia 1 Min Read

Knowledge about the different subtypes of and mutations within NSCLC has increased dramatically in the past 10 years. Here, Yvonne…

Improving the Cancer Journey: update and the role of pharmacists

Acute Lymphoblastic Leukemia 1 Min Read

Integrated healthcare is vital to provide the optimal care to cancer patients at all stages, from diagnosis to remission and…

The Bell Lap Diaries – Cancers Wind Runners

Acute Lymphoblastic Leukemia 1 Min Read

Beating cancer takes more than good luck and a good doctor, a high-tech medical center and exotic drugs. It takes…

The Use And Sequencing Of Tyrosine Kinase Inhibitors (TKI’s) In Hepatocellular Carcinoma (HCC)

Acute Lymphoblastic Leukemia 1 Min Read

Only one TKI is approved in a first line setting. Joining us from the 2018 Gastrointestinal Cancers Symposium is Dr.…

The Surveillance And The Management Of Gastroesophageal Cancer

Acute Lymphoblastic Leukemia 1 Min Read

Dr. Khaldoun Almhanna, MD, MPH, Department of Gastrointestinal Oncology, Moffitt Cancer Center, Associate Professor of Oncology, University of South Florida…

The Improvements And Changes To The Staging of Esophageal Cancer

Acute Lymphoblastic Leukemia 1 Min Read

The AJCC guidelines have incorporated several new features, Kenneth Wang, MD, Director of Advanced Endoscopy Group & Esophageal Neoplasia Clinic,…

Aims and impacts of the 100,000 Genomes Project

Acute Lymphoblastic Leukemia 1 Min Read

The exciting 100,000 Genomes Project has the potential to transform the way patients are cared for. Speaking from the American…

The ReDOS Study and How Using Dose Escalation of Stivarga (regorafenib) Is a Good Approach For A Hard To Tolerate Drug

Acute Lymphoblastic Leukemia 1 Min Read

Stivarga (regorafenib) is an effective drug but not one that is easily tolerable. Howard Hochster, MD, talks to us about…

The 100,000 Genomes Project: an update

Acute Lymphoblastic Leukemia 1 Min Read

The 100,000 Genomes Project is an exciting NHS programme, which aims to sequence 100,000 genomes from patients with rare diseases…

The TAP CLARITY study: latest results and future plans

Acute Lymphoblastic Leukemia 1 Min Read

Bloodwise’s Trials Acceleration Programme (TAP) aims to boost the number and speed of hematological oncology studies in the UK. Here,…

Venetoclax combination therapy for relapsed CLL

Acute Lymphoblastic Leukemia 1 Min Read

While single agents are able to control relapsed chronic lymphocytic leukemia (CLL) well, they do not provide a cure. In…

Smoking and lung cancer screening

Acute Lymphoblastic Leukemia 1 Min Read

The issue of smoking and lung cancer screening poses many questions. Speaking from the British Thoracic Oncology Group (BTOG) Annual…

Can we translate the benefits of lung cancer screening to the clinic?

Acute Lymphoblastic Leukemia 1 Min Read

It widely agreed that we need to identify better methods of detecting lung earlier. There has been great data suggesting…

Rapid diagnostic pathways for lung cancer

Acute Lymphoblastic Leukemia 1 Min Read

Reducing the length of diagnostic pathways can increase the number treatment options available and enable better patient experiences. Here, Neal…

Lung cancer screening trials: NELSON and NLST

Acute Lymphoblastic Leukemia 1 Min Read

Prior to the evaluation of whether lung cancer screening should be adopted, its impact on patient survival must be thoroughly…

Screening for lung cancer in the UK: progress and considerations

Acute Lymphoblastic Leukemia 1 Min Read

The early detection of lung cancer is an exciting field with the potential to greatly improve patient survival. Currently, the…

Introducing the National Optimal Lung Cancer Pathway (NOLCP) in the UK

Acute Lymphoblastic Leukemia 1 Min Read

The National Optimal Lung Cancer Pathway (NOLCP) was a much-discussed topic at the British Thoracic Oncology Group (BTOG) Annual Conference…

Does the UK need a National Optimal Lung Cancer Pathway?

Acute Lymphoblastic Leukemia 1 Min Read

Long waits for and between treatments, leading to worse outcomes for patients, are unacceptable. Improved care pathways are required to…

The NLCA annual report 2017: findings for lung cancer care in the UK

Acute Lymphoblastic Leukemia 1 Min Read

The 2017 National Lung Cancer Audit (NCLA) report launched at the British Thoracic Oncology Group (BTOG) Annual Conference 2018, held…

Improving lung cancer care pathways: the NLCA and the NOLCP

Acute Lymphoblastic Leukemia 1 Min Read

The findings of the National Lung Cancer Audit (NCLA) annual reports provide a means to identify where lung cancer care…

The National Lung Cancer Audit: improving lung cancer care

Acute Lymphoblastic Leukemia 1 Min Read

The British Thoracic Oncology Group (BTOG) Annual Conference 2018, held in Dublin, Ireland, hosted the launch of the latest National…

The role of pharmacists in the adoption of novel cancer immunotherapies

Acute Lymphoblastic Leukemia 1 Min Read

As traditional treatments for cancer are being surpassed by immunotherapies, the way in which healthcare providers deliver services must change.…

The impact of novel NSCLC immunotherapies

Acute Lymphoblastic Leukemia 1 Min Read

The landscape of NSCLC treatment is evolving rapidly. In this interview, Yvonne Summers, BSc, MB ChB, MSc, PhD, FRCP from…

Key messages on prostate cancer treatment from BOPA 2017

Acute Lymphoblastic Leukemia 1 Min Read

The British Oncology Pharmacy Association (BOPA) 20th Annual Symposium 2017 in Glasgow, UK revealed the latest clinical updates on prostate…

Prostate cancer precision medicine

Acute Lymphoblastic Leukemia 1 Min Read

Targeted therapy for prostate cancer is a promising field, which is set to grow in the coming year. Here, Robert…

Exciting advances in systemic therapy for prostate cancer: docetaxel and abiraterone

Acute Lymphoblastic Leukemia 1 Min Read

The identification of effective systemic medications for prostate cancer has been relatively recent and this field is now making exciting…

Multiple Strategies to Individualize Gastroesophageal Cancer Patients

Acute Lymphoblastic Leukemia 1 Min Read

At the 2018 Gastrointestinal Cancers Symposium, David Ilson, MD, PhD, from the Memorial Sloan Kettering Cancer Center talks about a…

Results of The ReDOS Study Affecting The Dosage of Stivarga (regorafenib) to Patients

Acute Lymphoblastic Leukemia 1 Min Read

The common discussion of where to start a patients dosage of regorafenib. Steven J. Cohen, MD, the Chief of the…

Hepatocelluar Carcinoma (HCC) Treatment Response Through Imaging Assessment

Acute Lymphoblastic Leukemia 1 Min Read

Determining the progression and the responses of Hepatocellular Carcinoma (HCC). Professor Andrew X. Zhu, MD, PhD from Harvard Medical School…

Using EGFR Antibodies as a First Line Therapy Depending on Tumor Sidedness

Acute Lymphoblastic Leukemia 1 Min Read

The choice of first line therapy differs on tumor sidedness. Professor Alan P. Venook, MD, joins us from the 2018…

Promising Novel Agents That Can Change the Treatment Landscape – FLT3 and IDH1 Inhibitors, Luspatercept

Acute Lymphoblastic Leukemia 1 Min Read

Sudipto Mukherjee, MD from Cleveland Clinics discusses promising novel agents that can change the treatment landscape and FLT3 and IDH1…

Hopeful for the FDA Approval of the IDH1 Inhibitor – New generation of inhibitors like FLT3 are hopefully more effective

Acute Lymphoblastic Leukemia 1 Min Read

Jonathan Gerber, MD from Levine Cancer Institute discusses hopeful for the FDA approval of the IDH1 inhibitor and new generation…

The importance of BTOG for multiprofessional communication

Acute Lymphoblastic Leukemia 1 Min Read

The British Thoracic Oncology Group (BTOG) Annual Conference 2018, held in Dublin, Ireland, had a record number of attendees, following…

Lung cancer care: the technology is there, but what else is needed?

Acute Lymphoblastic Leukemia 1 Min Read

At the British Thoracic Oncology Group (BTOG) Annual Conference 2018, held in Dublin, Ireland, we asked a number of experts…

The current landscape of radiotherapy services in the UK

Acute Lymphoblastic Leukemia 1 Min Read

There have been great improvements in radiotherapy (RT) services in the UK over the past 10 years; however, there is…

Shaking things up: modernizing radiotherapy services in England

Acute Lymphoblastic Leukemia 1 Min Read

Radiotherapy (RT) services in England are being shaken up in a reorganization, which was a hot topic at the British…

Day 2 of BOPA 2017

Acute Lymphoblastic Leukemia 1 Min Read

Steve Williamson from the Northumbria Healthcare Trust, Newcastle upon Tyne, UK, and Chair of the 20 years anniversary British Oncology…

Day 1 Highlights from the chair of BOPA 2017

Acute Lymphoblastic Leukemia 1 Min Read

Steve Williamson from the Northumbria Healthcare Trust, Newcastle upon Tyne, UK, and Chair of the 20 years anniversary British Oncology…

Supportive care in cancer: The role of pharmacists

Acute Lymphoblastic Leukemia 1 Min Read

Pharmacists are integral to providing and developing supportive care in cancer. In this interview, the essential roles of the pharmacist…

Supportive care in cancer: implementation and regulation

Acute Lymphoblastic Leukemia 1 Min Read

Supportive care for cancer is a relatively new area and is set to grow as the need for it increases.…

The Enhanced Supportive Care initiative for cancer patients

Acute Lymphoblastic Leukemia 1 Min Read

Supportive care for patients with cancer is becoming increasingly important, with advances in care meaning more people are surviving and…

New Forms of Interferon Have Improved Side-Effect Profiles – Pegylated Interferon and Ropeginterferon Lasts Much Longer

Acute Lymphoblastic Leukemia 1 Min Read

Aaron Gerds, MD from Cleveland Clinics discusses new forms of interferon have improved side-effect profiles and pegylated interferon and ropeginterferon…

Personalized Prediction Model for Myelodysplastic Syndromes – Certain mutations predict non-malignant conditions

Acute Lymphoblastic Leukemia 1 Min Read

Sudipto Mukherjee, MD from Cleveland Clinics discusses personalized prediction model for Myelodysplastic Syndromes and certain mutations predict non-malignant conditions at…

New Agents Becoming Available for the 1st time in Decades – What agents can be safely combined in pre & post transplant therapy

Acute Lymphoblastic Leukemia 1 Min Read

Jonathan Gerber, MD from Levine Cancer Institute discusses new agents becoming available for the 1st time in decades and what…

Two Areas That Potentially Cut Down Rehospitalizations – Follow patients to be on top of their health and manage symptoms

Acute Lymphoblastic Leukemia 1 Min Read

Sudipto Mukherjee, MD from Cleveland Clinics discusses two areas that potentially cut down rehospitalizations and follow patients to be on…

Patients Showed Symptomatic Relief in Phase I Trial of Glasdegib – 35% of Patients had at least a 20% improvement in their Symptom Burden

Acute Lymphoblastic Leukemia 1 Min Read

Aaron Gerds, MD from Cleveland Clinics discusses patients showed symptomatic relief in Phase I Trial of Glasdegib and 35% of…

9 Out of 10 Achieved Remission with Hypomethylating Agent – Next phase is to expand as a viable approach for elderly patients

Acute Lymphoblastic Leukemia 1 Min Read

Jonathan Gerber, MD from Levine Cancer Institute discusses 9 out of 10 achieved remission with Hypomethylating agent and next phase…

Preliminary Findings of Unplanned Hospital Readmissions – Conclusive Data may identify patients to cut down readmission rates

Acute Lymphoblastic Leukemia 1 Min Read

Sudipto Mukherjee, MD from Cleveland Clinics discusses preliminary findings of unplanned hospital readmissions and conclusive data may identify patients to…

Phase 2 Trial of Glasdegib in Myelofibrosis Was Not Launched – Due to modest overall response in clinical activity

Acute Lymphoblastic Leukemia 1 Min Read

Aaron Gerds, MD from Cleveland Clinics discusses Phase 2 Trial of Glasdegib in myelofibrosis was not launched – due to…

Predicting Multiple Rehospitalizations After Initial Admission – Subsets of patients who have Advanced Hematologic Malignancies

Acute Lymphoblastic Leukemia 1 Min Read

Sudipto Mukherjee, MD from Cleveland Clinics discusses predicting multiple rehospitalizations after initial admission – subsets of patients who have advanced…

Changed the Strategy of Chemotherapy and Transplants Gentle upfront then the intensive strategy for curative transplant

Acute Lymphoblastic Leukemia 1 Min Read

Jonathan Gerber, MD from Levine Cancer Institute discusses changed the strategy of chemotherapy and transplants and gentle upfront then the…

New Information for Normal Plasma Cell Biology Findings were used to develop new treatments like, MCL-1

Acute Lymphoblastic Leukemia 1 Min Read

Rafael Fonseca, MD from the Mayo Clinic in Phoenix, Arizona, discusses new information for normal plasma cell biology and findings…

TACTICS Trial Demonstrates Benefit With TACE Plus Sorafenib in Unresectable HCC

Acute Lymphoblastic Leukemia 1 Min Read

Masatoshi Kudo, MD from Kindai University, Japan discusses TACTICS trial demonstrates benefit with TACE plus Sorafenib in unresectable HCC at…

TACE New Cancer Region Is Not Failure – TACE + Sorafenib Should Be Continued Even After New Cancer

Acute Lymphoblastic Leukemia 1 Min Read

Masatoshi Kudo, MD from Kindai University, Japan discusses TACE new cancer region is not failure and TACE + Sorafenib should…

TACE + Sorafenib May Change Standard in HCC – If Overall Survival Data is Positive then Standard of Care Will Change

Acute Lymphoblastic Leukemia 1 Min Read

Masatoshi Kudo, MD from Kindai University, Japan discusses TACE + Sorafenib may change standard in HCC and if overall survival…

Real World Outcomes for Myeloma Patients Trial – Phase 3 Trial results can be reproduced using real world data from a database

Acute Lymphoblastic Leukemia 1 Min Read

Rafael Fonseca, MD from the Mayo Clinic in Phoenix, Arizona, discusses real world outcomes for myeloma patients trial and phase…

Regorafenib Dose Optimization Study (ReDOS) Weekly escalation Regorafenib 80 to 160 mg-day superior to start dose of 160

Acute Lymphoblastic Leukemia 1 Min Read

Cathy Eng, MD, FACP GASTROINTESTINAL MEDICAL ONCOLOGY – MD Anderson discusses the Regorafenib Dose Optimization Study (ReDOS) and how a…

Combo Cobimetinib & Atezolizumab in Metastatic Colorectal Cancer 8Response Rate with an Overall Survival of 13-14 months

Acute Lymphoblastic Leukemia 1 Min Read

Cathy Eng, MD, FACP GASTROINTESTINAL MEDICAL ONCOLOGY – MD Anderson discusses the combination of Cobimetinib & Atezolizumab in Metastatic Colorectal…

Checkmate 142 Nivolumab & Ipilimumab 55Response Rate in MSI High

Acute Lymphoblastic Leukemia 1 Min Read

Cathy Eng, MD, FACP GASTROINTESTINAL MEDICAL ONCOLOGY – MD Anderson discusses the trial Checkmate 142 Nivolumab & Ipilimumab and how…

Checking for CEA in Metastatic Anal Cancer Benefit for Ordering a CEA as a Biologic Marker in Anal Cancer

Acute Lymphoblastic Leukemia 1 Min Read

Cathy Eng, MD, FACP GASTROINTESTINAL MEDICAL ONCOLOGY – MD Anderson discusses Checking for CEA in Metastatic Anal Cancer and how…

Glasdegib Intended to be Long-Term Goal for Treating Myelofibrosis – Isolating the roots of the disease is a focus in the field going forward

Acute Lymphoblastic Leukemia 1 Min Read

Aaron Gerds, MD from Cleveland Clinics discusses Glasdegib intended to be long-term goal for treating myelofibrosis and isolating the roots…

Longer-lasting Interferon being developed: Ropeginterferon – Ongoing Randomized Trial in Polycythemia Vera

Acute Lymphoblastic Leukemia 1 Min Read

Aaron Gerds, MD from Cleveland Clinics discusses longer-lasting interferon being developed: Ropeginterferon and ongoing randomized trial in polycythemia vera at…

CD40 Antibody APX005M, Nivolumab & Chemotherapy Phase 1b 2 Study to Explore Combo Chemotherapy and 2 Immunotherapy Agents

Acute Lymphoblastic Leukemia 1 Min Read

David Feltquate Head of Early Clinical Development at BRISTOL-MYERS SQUIBB discusses the the phase 1b/2 open-label study which will explore…

ONC201 Safety and Advantages

Acute Lymphoblastic Leukemia 1 Min Read

Peter Anderson, MD, Pediatric Hematology Oncology and Blood and Marrow Transplantation of Cleveland Clinic discusses the ONC201 Safety and Advantages…

ONC201 Patient Disqualifiers Peritoneal Metastasis, Esophageal Metastasis and Too Sick to Travel

Acute Lymphoblastic Leukemia 1 Min Read

Peter Anderson, MD, Pediatric Hematology Oncology and Blood and Marrow Transplantation of Cleveland Clinic discusses the ONC201 Patient Disqualifiers such…

ONC201 Moving to Phase III Establish Better Quality of Life & Tumor Markers May Lead to Fastrack

Acute Lymphoblastic Leukemia 1 Min Read

Peter Anderson, MD, Pediatric Hematology Oncology and Blood and Marrow Transplantation of Cleveland Clinic discusses moving ONC201 from Phase 2…

Patient Enrollment for Phase 2 ONC201 Karnofsky Performance 60 and Good Kidney and Liver Performance

Acute Lymphoblastic Leukemia 1 Min Read

Peter Anderson, MD, Pediatric Hematology Oncology and Blood and Marrow Transplantation of Cleveland Clinic discusses the the Patient Enrollment for…

Phase 2 ONC201 Neuroendocrine Desmoplastic Small Round Cell Tumor Neuroblastoma Clear-Cell Carcinoma

Acute Lymphoblastic Leukemia 1 Min Read

Peter Anderson, MD, Pediatric Hematology Oncology and Blood and Marrow Transplantation of Cleveland Clinic discusses the Phase 2 ONC201 Patient…

Phase 2 ONC201 Patient Selection Pheochromocytoma and Paraganglioma – May Reduce Hypertension

Acute Lymphoblastic Leukemia 1 Min Read

Peter Anderson, MD, Pediatric Hematology Oncology and Blood and Marrow Transplantation of Cleveland Clinic discusses the Phase 2 ONC201 Patient…

Results of Phase I Trial in Heavily Pre-Treated Myelofibrosis – Dysgeusia and muscle spasms were among the negative side-effects

Acute Lymphoblastic Leukemia 1 Min Read

Aaron Gerds, MD from Cleveland Clinics discusses results of Phase I trial in heavily pre-treated myelofibrosis and dysgeusia and muscle…

Results of Randomized Trial of ELd Treatment – Primary endpoint was met with ORR of 88with ELd in Japanese patients

Acute Lymphoblastic Leukemia 1 Min Read

Mitsuo Hori, MD from Ibaraki Prefectural Central Hospital discusses results of randomized trial of ELd treatment and primary endpoint was…

CAR-T Cell Therapy as Potential Venue for Multiple Myeloma – Bispecific Antibody may provide immuno-oncology in safer venue

Acute Lymphoblastic Leukemia 1 Min Read

Joshua Richter, MD from John Theurer Cancer Center discusses CAR-T Cell therapy as potential venue for multiple myeloma and bispecific…

Phase I-II Trial of Glasdegib in Myelofibrosis – Glasdegib is a Hedgehog Pathway Inhibitor

Acute Lymphoblastic Leukemia 1 Min Read

Aaron Gerds, MD from Cleveland Clinics discusses phase I-II trial of Glasdegib in myelofibrosis and that Glasdegib is a Hedgehog…

ELOQUENT-2 Study in Japanese Patients – Safety was consistent with patients in relapsed refractory myeloma

Acute Lymphoblastic Leukemia 1 Min Read

Mitsuo Hori, MD from Ibaraki Prefectural Central Hospital discusses ELOQUENT-2 study in Japanese patients safety was consistent with patients in…

GBR 1342: Bispecific T cell engager – GBR 1342 attaches to CD38 Receptor and engages T Cells

Acute Lymphoblastic Leukemia 1 Min Read

Joshua Richter, MD from John Theurer Cancer Center discusses GBR 1342: A bispecific T cell engager that attaches to CD38…

A New Treatment Option for Uncommon EGFR Mutations (BMIC-023)

Acute Lymphoblastic Leukemia 1 Min Read

Dr. Jack West reviews the new FDA approval for afatinib (Gilotrif) for specific uncommon EGFR mutations, including G719X, L861Q, and…

FDA Approval of Several CAR-T Cell Therapies – Hope to make new therapies accessible to patients

Acute Lymphoblastic Leukemia 1 Min Read

Robert Rifkin, MD from Rocky Mountain Cancer Center discusses FDA approval of several CAR-T Cell therapies and hope to make…

New Cancer Research Technologies in Recent Years – Access new information and a better understanding of cancer progression

Acute Lymphoblastic Leukemia 1 Min Read

Mark Bustoros, MD from Dana-Farber Cancer Institute discusses new cancer research technologies in recent years and access new information and…

Development of a Predictive Model of MM Patient Outcomes – Based on Treatment Class Transitions using patient registry

Acute Lymphoblastic Leukemia 1 Min Read

Robert Rifkin, MD from Rocky Mountain Cancer Center discusses development of a predictive model of multiple myeloma patient outcomes and…

Baseline Disease Characteristics & Diagnostic Patterns for NDMM – Observations over time in Cohort 1 and Cohort 2

Acute Lymphoblastic Leukemia 1 Min Read

Robert Rifkin, MD from Rocky Mountain Cancer Center discusses baseline disease characteristics & diagnostic patterns for NDMM – observations over…

Blood Biopsies Instead of Bone Marrow – New findings from blood biopsy add to the information

Acute Lymphoblastic Leukemia 1 Min Read

Jens Lohr, MD from Dana-Farber Cancer Institute discusses blood biopsies instead of bone marrow and new findings from blood biopsy…

Center for Prevention of Progression of Blood Cancers – Focused on precursor conditions of blood cancers

Acute Lymphoblastic Leukemia 1 Min Read

Mark Bustoros, MD from Dana-Farber Cancer Institute discusses center for prevention of progression of blood cancers and focused on precursor…

Survival and Depth of Response in African American and Non-AA Patients – Conflicting data on the virulence of Myeloma for African American patients

Acute Lymphoblastic Leukemia 1 Min Read

Robert Rifkin, MD from Rocky Mountain Cancer Center discusses survival and depth of response in African American and Non-AA patients…

Cases When Cell Free DNA is Most Beneficial – Specific patient populations and stage of disease

Acute Lymphoblastic Leukemia 1 Min Read

Jens Lohr, MD from Dana-Farber Cancer Institute discusses cases when cell free DNA is most beneficial and specific patient populations…

Connect® Multiple Myeloma Patient Registry – Eventually pool data from Connect® for a larger database of registry

Acute Lymphoblastic Leukemia 1 Min Read

Robert Rifkin, MD from Rocky Mountain Cancer Center discusses Connect® multiple myeloma patient registry and eventually pool data from Connect®…

Next Step for Phase 1 GBR 1342 Studies – Identify the maximum tolerated dose to proceed to Phase 2

Acute Lymphoblastic Leukemia 1 Min Read

Joshua Richter, MD from John Theurer Cancer Center discusses next step for Phase 1 GBR 1342 studies and identifying the…

Collaborators Provide Samples to Dana Farber Institute – Large amount of samples provides stronger results for Smoldering Multiple Myeloma

Acute Lymphoblastic Leukemia 1 Min Read

Mark Bustoros, MD from Dana-Farber Cancer Institute discusses collaborators provide samples to Dana Farber Institute and large amount of samples…

This Phase 3 Trial has Shown Improved Overall Survival – Toxicity Profile has been stable with prolonged exposure to drugs

Acute Lymphoblastic Leukemia 1 Min Read

Keith Stewart, MD from Mayo Clinic Division of Hematology and Oncology discusses this phase 3 trial has shown improved overall…

Phase 2 Trials of BCMA Targeted Therapy – Find safety, toxicity, and efficacy in a larger patient population

Acute Lymphoblastic Leukemia 1 Min Read

Sagar Lonial, MD from Winship Cancer Institute of Emory University discusses phase 2 trials of BCMA targeted therapy and finding…

Carflizomib is Extraordinarily Active in Myeloma Mainstay drug for physicians and patients

Acute Lymphoblastic Leukemia 1 Min Read

Robert Rifkin, MD from Rocky Mountain Cancer Center discusses Carflizomib is extraordinarily active in myeloma and mainstay drug for physicians…

Limitations of Blood Biopsy – One must have enough circulating DNA in the bloodstream

Acute Lymphoblastic Leukemia 1 Min Read

Jens Lohr, MD from Dana-Farber Cancer Institute discusses limitations of blood biopsy and that one must have enough circulating DNA…

The First Phase 3 Trial of a New Drug Added to a Standard – Must use Triplet Therapy early in the diseases course

Acute Lymphoblastic Leukemia 1 Min Read

Keith Stewart, MD from Mayo Clinic Division of Hematology and Oncology discusses the first phase 3 trial of a new…

Inclusion and Exclusion Criteria of GBR 1342 – Trial designed for patients who have no proven therapy available

Acute Lymphoblastic Leukemia 1 Min Read

Joshua Richter, MD from John Theurer Cancer Center discusses inclusion and exclusion criteria of GBR 1342 and the trial designed…

Improve the Prediction of Progression of Multiple Myeloma

Acute Lymphoblastic Leukemia 1 Min Read

Mark Bustoros, MD from Dana-Farber Cancer Institute discusses on how to improve the prediction of progression of multiple myeloma at…

Data Shows Safety of Drugs for Clinicians & Academia Data is accessible to Private Practice Clinicians and Academia now

Acute Lymphoblastic Leukemia 1 Min Read

Sagar Lonial, MD from Winship Cancer Institute of Emory University discusses data shows safety of drugs for clinicians & academia…

Carflizomib Doing Patterns – Data presented for appropriate dosing of Carfilzomib

Acute Lymphoblastic Leukemia 1 Min Read

Robert Rifkin, MD from Rocky Mountain Cancer Center discusses Carflizomib doing patterns and the data presented for appropriate dosing of…

Advantages of Blood Biopsy Blood draw is comfortable and convenient for patients

Acute Lymphoblastic Leukemia 1 Min Read

Jens Lohr, MD from Dana-Farber Cancer Institute discusses advantages of blood biopsy and how blood draw is comfortable and convenient…

GBR 1342 Studies in Phase 1 – Search for the maximum tolerated dose

Acute Lymphoblastic Leukemia 1 Min Read

Joshua Richter, MD from John Theurer Cancer Center discusses GBR 1342 studies in phase 1 and search for the maximum…

Phase 2 Trial of Dasatinib with Philadelphia Chromosome+ ALL – Results were similar to studies with imatnib

Acute Lymphoblastic Leukemia 1 Min Read

Stephen Hunger, MD from Children’s Hospital of Philadelphia discusses phase 2 trial of Dasatinib with Philadelphia Chromosome+ ALL and how…

Largest Study on Genomic Smoldering Multiple Myeloma – 135 patients were studied with 186 samples

Acute Lymphoblastic Leukemia 1 Min Read

Mark Bustoros, MD from Dana-Farber Cancer Institute discusses largest study on genomic smoldering Multiple Myeloma and 135 patients were studied…

Analysis from the Randomized Phase 3 Aspire Trial – Carfilzomib, Lenalidomide, & Dexamethasone V. Lenalidomide & Dexamethasone

Acute Lymphoblastic Leukemia 1 Min Read

Keith Stewart, MD from Mayo Clinic Division of Hematology and Oncology discusses the analysis from the randomized phase 3 Aspire…

Trial Combines Daratumumab with Carfilzomib & Dexamethasone – First Trial combining all drugs in a larger patient experience

Acute Lymphoblastic Leukemia 1 Min Read

Sagar Lonial, MD from Winship Cancer Institute of Emory University discusses trial combines Daratumumab with Carfilzomib & Dexamethasone and the…

Poster #1 Phase 2 Study of Daratumumab+ CyBorD – Dose was split into two days to reduce infusion time

Acute Lymphoblastic Leukemia 1 Min Read

Robert Rifkin, MD from Rocky Mountain Cancer Center discusses poster #1 phase 2 study of Daratumumab+ CyBorD and the dose…

Cell Free DNA Sequencing – DNA is isolated in the bloodstream instead of bonemarrow

Acute Lymphoblastic Leukemia 1 Min Read

Jens Lohr, MD from Dana-Farber Cancer Institute discusses cell free DNA sequencing and DNA is isolated in the bloodstream instead…

Further Promising Studies in 2018 – CAR-T Cell Therapy, Polatuzumab, Checkpoint Inhibitors

Acute Lymphoblastic Leukemia 1 Min Read

John M Burke, MD from Rocky Mountain Cancer Centers discusses further promising studies in 2018 – CAR-T cell therapy, Polatuzumab,…

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