Meletios Dimopoulos, MD, of the University of Athens School of Medicine, Athens, Greece, gives an overview of the OPTIMISMM trial (NCT01734928) at the 2018 Society of Hematologic Oncology (SOHO) Annual Meeting in Houston, TX. This trial compared progression free survival (PFS) of dexamethasone/bortezomib and a triplet of dexamethasone, bortezomib and pomalidomide in patients with multiple myeloma (MM) that have previously been treated with lenalidomide. The positive PFS data from the triplet regimen, even in patients who have acquired resistance to lenalidomide, suggests a positive future for this therapy.
OPTIMISMM: benefits of a new triplet therapy for MM patients relapsing on lenalidomide
