The therapeutic potential for Waldenströms macroglobulinemia (WM) is widening, with our growing understanding and knowledge of the genetics behind this disease. In this interview at the 1st European Myeloma Network (EMN) Meeting, held in Turin, Italy, Steven Treon, MD, PhD, of the Dana-Farber Cancer Institute, Boston, MA, reviews the current and prospective therapies available for WM. He highlights the exciting work being done with BTK inhibitors and monoclonal antibodies, including acalabrutinib, venetoclax and daratumumab, which are advancing the repertoire of targeted therapies.