With the NHS opening two high energy proton beam centers next year, optimism is high in the medical community for the benefits that this could bring to many cancer patients over the coming years. However, as explained here by Adrian Crellin, MB, BChir, MA, FRCP, FRCR, of Leeds Teaching Hospitals NHS Trust, Leeds, UK, there is still a high degree of uncertainty regarding the dosage and biological quirks of the treatment, especially when integrated with other drugs, and so the proper evaluation of proton beam therapy under academic contexts is essential for the safety of patients. This video was recorded at the 2017 National Cancer Research Institute (NCRI) Conference in Liverpool, UK.