The identification of novel therapeutic targets is essential for the improved treatment of hematological cancer, particularly due to the development of drug resistance. Here, Constantine Tam, MD, FRACP, FRCPA, of Peter MacCallum Cancer Centre, Melbourne, Australia, discusses a new therapeutic target in the field of chronic lymphocytic leukemia (CLL): ROR1. Dr Tam highlights the promising results of an early phase study of an ROR1-directed monoclonal antibody, as well as what the results of this study can tell us about this target and future therapy development.
