Myeloproliferative neoplasms are complex diseases, with new research constantly updating our understanding of risk factors that may cause the diseases to develop or certain complications that can arise from them. The Myeloproliferative Neoplasms Advances Day 2017 in London, UK, presented cutting-edge updates in the field. In this interview, Claire Harrison, MD, FRCP, FRCPath, of Guys and St Thomas Hospital NHS Foundation Trust, London, UK, gives an overview of the exciting talks given at the conference, including the TAMARIN study (ISRCTN65011803), prognostic modelling, fresh perspectives on drugs such as warfarin, and the future of genetic sequencing.