The Multiple Myeloma Research Foundation (MMRF) has been very active throughout 2017. Here, Daniel Auclair, PhD, of the MMRF, Norwalk, CT, discusses the exciting work of the organization that was presented at the American Society of Hematology (ASH) 2017 Annual Meeting and Exposition in Atlanta, GA. Dr Auclair discusses important findings from the CoMMpass study (NCT145429), big machine learning, validating the impact of transplant on outcomes depending upon the molecular type, and the molecular profiling protocol created. He also highlights the organization’s investments in prevention and early disease understanding.