At the British Thoracic Oncology Group (BTOG) Annual Conference 2018, held in Dublin, Ireland, we asked a number of experts what the key unanswered question in lung cancer is currently. The general consensus was that there were many questions, but each speaker had their own take. Here, Jeanette Dickson, MD, FRCR, of East and North Hertfordshire NHS Foundation Trust, Stevenage, UK, gives her answer, covering the hot topic of lung cancer screening, as well as treatment combination and sequencing.