Pierluigi Porcu, MD, from the Sidney Kimmel Cancer Center, Philadelphia, PA, discusses recent clinical developments that have provided healthcare professionals with a clear landscape of the disease. Dr Porcu highlights how the creation of international registries, filled with an abundance of patient data sets, has enhanced the level of understanding of the disease. He also states that knowledge regarding the pathology and genetic profile of CTCL has significantly developed, hence the rise of precision medicine for the disease. He excitedly speaks about the success pre-clinical models of disease have had in practice. This was recorded at the 2018 Society of Hematologic Oncology (SOHO) Annual Meeting in Houston, TX