The University of Birmingham has partnered with Leuka, NHS Blood and Transplant, and Anthony Nolan to deliver the UKs first large-scale clinical trials programme for patients who receive stem cell transplants; IMPACT. In this interview, Charles Craddock, CBE, FRCP (UK), FRCPath, DPhil, of the University of Birmingham, Birmingham, UK, discusses the aims of IMPACT, highlighting the huge unmet need it will fill, as well as the potential insights into the biological mechanisms of transplant it could provide. Prof. Craddock also provides an overview of the structure of IMPACT, including the first three studies that are taking place as part of the initiative. This video was recorded at the American Society of Hematology (ASH) 2017 Annual Meeting and Exposition in Atlanta, GA.