In this video, Raul Cordoba, MD, PhD, outlines the pre-clinical studies that are occurring at the Fundacion Jimenez Diaz University Hospital, Madrid, Spain, including baseline analysis of patients immune systems to assess absolute lymphocyte counts, as well as CD3, CD4 and CD8 T-cell subsets, in order to predict the outcome of treating elderly patients with immunotherapy. This could help identify predictive factors of outcome in elderly patients, thus minimizing the chance of adverse complications. This video was recorded at the 23rd Congress of the European Hematology Association (EHA) 2018, held in Stockholm, Sweden.