There is increasing evidence to suggest that chemotherapy contributes to changes in cognition. In this interview, Ginah Nightingale, PharmD, BCOP, of Thomas Jefferson University, Philadelphia, PA, describes the pathways through which chemotherapy may contribute to deficits in cognition in patients. This interview was recorded at the 2018 Hematology/Oncology Pharmacy Association (HOPA) Annual Conference, held in Denver, CO.