Holistic therapies are often viewed unfavorably by the medical community, with many clinicians preferring to solely focus on pharmacological treatments. However, for chronic illnesses such as MPNs, where there is no drug that can currently cure the condition, treatments generally aim to reduce the burden of the disease as much as possible. In this interview, Ruben Mesa, MD, of UT Health San Antonio Cancer Center, San Antonio, TX, USA, discusses some of his clinics exploration of various complementary therapies for patients with MPNs, including cognitive, physical and nutritional therapies. This video was recorded at the Myeloproliferative Neoplasms Advances Day 2017, London, UK.