Speaking from the American Society of Oncology (ASCO) 2018 Annual Meeting, held in Chicago, IL, Guillermo Garcia-Manero, MD, of the University of Texas MD Anderson Cancer Center, Houston, TX, gives an overview of his favourite oral abstract presentations from this years meeting. He speaks about the general themes of the presentations submitted, and then in more detail about the presentations he thought were most relevant to clinical practice. These included studies examining the following: the effect of the IDH1 inhibitor ivosidenib on relapsed/refractory acute myeloid leukemia (AML); the safe treatment of early stage myelodysplastic syndrome (MDS) with low doses of hypomethylating agents; bosutinib vs. the standard of care in chronic myeloid leukemia (CML); and the expansion of NK-cells in the context of HPC transplantation.