The immunoscore is a predictive tool that looks at a cancer patients adaptive immunity to predict survival and recurrence, amongst other uses. In this interview, Jerome Galon, PhD, of Cordeliers Research Center, Paris, France, gives an overview of how a low immunoscore, indicating a cold tumor with few immune cells in it, can be changed through treatments such as immunotherapy or anti-EGFR therapies to stimulate immune activity inside the tumor, and increase the patients immunoscore. This video was recorded at the 2017 National Cancer Research Institute (NCRI) Conference, held in Liverpool, UK.