At the 42nd Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), held in Valencia, Spain, EBMT 2016 President Mohamad Mohty, MD, PhD, from Saint-Antoine Hospital, Paris, France, discusses graft-versus-host disease (GvHD), a complication that can occur after allogeneic transplantation and be a major barrier to the success of stem cell transplantation. Dr Mohty gives an overview of EBMT 2016 discussions, which address GvHD prophylaxis, pharmacologic agents and the role of polyclonal antibodies.