While the treatment landscape of chronic lymphocytic lymphoma (CLL) has been exciting with many breakthrough therapies, there are still key areas for improvement. Speaking from the British Society for Haematology (BSH) 2018 Annual Meeting in Liverpool, UK, Peter Hillmen, MBChB, PhD, FRCP, FRCPath, from the University of Leeds and Leeds Teaching Hospitals NHS Trust, Leeds, UK stresses the importance of moving novel therapies rapidly into Phase III trials if they have shown promising results. Prof. Hillmen also talks about banking samples and translational research to improve understanding and refine treatment.