Although researchers are aware of the fact that epigenetic factors play a significant role in the development of multiple myeloma (MM), we do not yet understand these factors to the level we do the genomic components of the disease. Speaking from the Myeloma 2017 meeting held in Edinburgh, UK, Felipe Prosper Cardoso, MD, from the University of Navarra, Pamplona, Spain, explains why this is the case, and discusses his talk at the meeting, where he covered a new high-throughput technology, designed to study the changes in chromatin structure between MM and non-MM cells, and our current understanding of the epigenetics of MM.