This is an incredibly exciting time for multiple myeloma (MM) research. In this video, some of the most interesting topics presented at the Myeloma 2017 meeting in Edinburgh, UK, are discussed by Daniel Auclair, Senior Vice President of Research, MMRF, Irene Ghobrial, MD from the Dana-Farber Cancer Institute, Boston, MA, Jonathan Keats, PhD of the Translational Genomics Research Institute, Phoenix, AZ, Nina Shah, MD of UCSF Medical Center, San Francisco, CA and Larry Boise, PhD from Emory University School of Medicine, Atlanta, GA. The developing reality of liquid biopsies, emerging novel subtypes of MM, ground-breaking advances in immunotherapies and exciting improvements in the understanding of resistance mechanisms are discussed. The experts interviewed also provide an overview of the techniques that we could soon see transitioned into clinical use.