There are an array of new strategies evolving to manage relapsed chronic lymphocytic leukemia (CLL). In this interview, George Follows, MA, BM, BCh, PhD, FRCP, FRCPath, from Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK, discusses the exciting UK CLL Forum analysis of patients treated with ibrutinib at first relapse. Dr Follows highlights the fascinating results identified between patients with early and late relapse. This interview was recorded at the British society for Hematology (BSH) 2018 Annual Scientific Meeting, held in Liverpool, UK.