At the 6th European Lung Cancer Conference (ELCC), held in Geneva, Switzerland, from 1316 April 2016, Martin Reck, MD, PhD, from LungenClinic Grosshansdorf, Grosshansdorf, Germany, discusses immunotherapy as a key theme of the conference, including current data and future concepts, efficacy in untreated patients, efficacy in combination approaches, and biomarker-based treatment selection.